大段同种骨移植5年后骨标本的病理表现  

The pathological study on bone allograft retrieved 5 years after implantation

作　　者：李幼忱[1] 陈秋[2] 周沫[1] 康悦[1] 

机构地区：[1]中国辐射防护研究院,山西省医用组织库,太原030006 [2]宁波市第六人民医院骨科,315040

出　　处：《中国骨肿瘤骨病》2010年第2期142-146,共5页Chinse Journal Of Bone Tumor And Bone Disease

摘　　要：目的通过对1例骨肿瘤保肢术5年后因骨折取出的同种骨标本的病理学分析,探讨大段同种骨移植后在体内的修复过程。方法6岁女孩股骨骨肉瘤切除,行深冻辐照同种股骨干移植,长度20cm,术后骨愈合良好,5年后因意外致植入骨中下段斜劈形骨折,手术取出部分骨折片,进行光镜和扫描电镜观察,取未植入的同种骨材料作为对照。结果植入骨外观与对照相似;植入骨内的部分管腔扩大、形态不规则,骨表面及扩大的哈氏管表面见薄层新骨,黏合线清晰,哈氏管附近骨陷窝内见骨细胞;骨折面大量吸收窝,可见破骨细胞和成骨细胞。结论植入骨内已出现再血管化和一定程度的骨吸收及新骨形成。Objective To investigate the healing process of massive bone allograft by analyzing the bone allograft sample retrieved 5 years after the implantation due to fracture. Methods The patient was a 6-years-old girl. Her femur was Salvaged with a radiated deep-frozen bone allografl which was a shaft of femur of 20cm. The bone union was good. However, the fracture of bone allograft occurred by accident 5 years after implantation. A piece of graft was removed and observed with light microscopy and scanning electron microscopy. The allografl product was used as the contrast. Results The implanted bone and the allografl product look the same. The canals in the allograft became larger and irregular. A thin seam of new bone on the outer surface of the graft and the surface of some enlarged haversian canals was seen with a demarcating cement line. Osteocyte was seen in the bone lacuna near haversian canal. Osteoclasts and osteoblasts were seen in the numerous Howship lacunas on the surface of fracture. Conclusions Revascularization, bone resorption and new bone formation already oecured in bone allograft.

关 键 词：同种骨移植 骨折 临床病理 

分 类 号：R361.2[医药卫生—病理学]