血管紧张素-(1-7)的生物学作用及其信号通路进展  

Research Advance in Biological Effects and Signal Transduction Pathways of Angiotensin-(1-7)

作　　者：肖红丽[1] 王艳[1] 孙芳芳[1] 阴赪宏[1] 

机构地区：[1]首都医科大学附属北京友谊医院感染暨急救医学科,北京100050

出　　处：《医学综述》2010年第9期1287-1290,共4页Medical Recapitulate

基　　金：北京市自然科学基金(7102038)

摘　　要：血管紧张素-(1-7)是肾素-血管紧张素系统中重要的终末活性产物,具有改善胰岛素抵抗、保护血管内皮、舒张血管、抑制心肌重构、保护肾脏等生物学作用,凭借的信号转导通路包括增强胰岛素受体/胰岛素受体底物蛋白1/磷脂酰肌醇3激酶/蛋白激酶B通路活性、负向调节AngⅡ/AT1受体激活的c-Src及其下游靶点细胞外信号调节激酶1/2和还原型烟酰胺腺嘌呤二核苷酸(磷酸)氧化酶等。Angiotensin-（1-7）is a biologically active terminal substance in the renin-angiotensin system.It can alleviate insulin resistance,protect vascular endothelial cells,dilate vascular vessels,suppress cardiac muscle reconstruct and protect kidney.The signal transduction pathways of angiotensin-（1-7）induce the activation of insulin signaling through the insulin receptor/insulin receptor substrate protein-1/phosphatidylinositol-3-kinase/Akt pathway,negatively modulates angiotensin Ⅱ/angiotensin Ⅱ type 1 receptor-activated c-Src,and its downstream targets extracellular signal-regulated kinase 1/2 and nicotinamide-adenine dinucleotide phosphate oxidase.The review describes the biological effects of angiotensin-（1-7）and its signal transduction pathways,including the basic components,adjustment mode and interaction with other signal transduction pathways.

关 键 词：血管紧张素-(1-7) 生物学作用 信号转导通路 

分 类 号：R363.2[医药卫生—病理学]