脱氧雪腐镰刀菌烯醇毒性作用研究进展  

Progress in Toxicity of Deoxynivalenol

作　　者：朱小明[1] 于爱莲[1] 

机构地区：[1]泰山医学院病原学教研室,山东泰安271000

出　　处：《医学综述》2010年第9期1294-1296,共3页Medical Recapitulate

基　　金：山东省科技攻关项目(2007GG30002016);山东省教育厅资助项目(J07YD04)

摘　　要：为了给真菌毒素的深入研究提供理论基础,现对国内外有关脱氧雪腐镰刀菌烯醇的毒性研究进行文献综述,重点概述近年来脱氧雪腐镰刀菌烯醇在细胞毒性、致畸、致突变和致癌方面的最新研究进展,并指出下一步的研究应侧重于脱氧雪腐镰刀菌烯醇的毒性机制、与人类疾病的关系以及多种真菌毒素的协同作用等几个方面。To provide theoretical basis for further study of mycotoxin,this article summarized the relative researches on toxic effect of deoxynivalenol at home and abroad,among which the recent development of cytotoxicity,teratogenicity,mutagenicity and carcinogenesis of deoxynivalenol is introduced emphaticallys.And this article pointed out the future research should be emphasized in several aspects as follows：toxic mechanism of deoxynivalenol,the relationship between deoxynivalenol and human disease,coordination function of several Fusarium and so on.

关 键 词：脱氧雪腐镰刀菌烯醇 细胞毒性 致畸性 致突变性 致癌作用 

分 类 号：R996.11[医药卫生—毒理学]