乳腺癌组织中MT1-MMP、VEGF的表达及其相关性  

The expression and corredation of MT1-MMP and VEGF in breast carcinoma

作　　者：陈艳波[1] 王彦博[1] 孙姗姗[1] 孙倩[1] 庞达[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨150040

出　　处：《实用肿瘤学杂志》2010年第2期149-151,155,共4页Practical Oncology Journal

摘　　要：目的 探讨MT1-MMP和VEGF在乳腺癌组织中的表达及其与乳腺癌临床病理特征间的关系.方法 采用免疫组织化学方法检测67例乳腺癌组织和癌旁正常组织中MT1-MMP和VEGF的表达情况,并与临床病理特征进行相关性分析.结果 MT1-MMP和VEGF在乳腺癌组织中的表达水平显著高于在癌旁正常组织中的表达水平（P＜0.05）.VEGF 和MT1-MMP在乳腺癌组织中的表达呈正相关（P=0.005）.VEGF的表达与乳腺癌的TNM分期和淋巴结转移相关（P＜0.05）;MT1-MMP表达与乳腺癌的TNM分期和腋窝淋巴结转移相关（P＜0.05）.结论 MT1-MMP和VEGF的过表达与乳腺癌的浸润转移有关,二者联合检测对判断乳腺癌的恶性程度和预后具有重要价值.Objective To explore the expression of MT1 - MMP and VEGF in breast carcinoma tissue and their association with the clinicopathological features of breast cancer. Methods The staining method was used to evaluate the expression of MT1 - MMP and VEGF in 67 specimens of breast carcinoma and adjacent normal tissues, and its correlations to clinicopathological features were analyzed. Results The expression level of the MT1 - MMP and VEGF in breast carcinoma tissues was markedly higher than that in the paraneoplastic breast tissue（P 〈0.05）. The expression of MT1 -MMP was positively correlated with the expression of VEGF in breast carcinoma tissues（ P =0.005 ）. The expressions of MT1 - MMP and VEGF were positively correlated to TNM stage and axillary lymph node metastasis （ P 〈 0.05 ）. Conclusions The increasing expressions of MT1 - MMP and VEGF were correlated with invasion and metastasis of breast carcinoma, combined examination of VEGF and MT1 - MMP can be of value in assessment of the malignancy and in prognostic evaluation of breast carcinoma.

关 键 词：乳腺癌 MT1-MMP VEGF 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]