丘脑出血继发脑室出血患者血浆内皮素-1的动态变化及临床意义  

Change of Plasma Endothelin-1 Level and Clinical Significance in Patients With Secondary Intraventricular Hemorrhage from Thalamic Hemorrhage

作　　者：陈勇军[1] 张新华[1] 邹伟[1] 刘淑云[1] 张平[1] 蒋福生[1] 

机构地区：[1]南华大学附属南华医院神经内科,湖南衡阳421002

出　　处：《南华大学学报（医学版）》2010年第1期107-108,125,共3页Journal of Nanhua University(Medical Edition)

摘　　要：目的研究丘脑出血继发脑室出血(SIHTH)患者不同时点血浆内皮素-1(ET-1)水平的变化及其与脑血管痉挛(CVS)发生的关系。方法23例SIHTH患者分为CVS组和无CVS组。CVS的判定采用经颅多普勒(TCD),放射免疫法测定ET-1水平,比较两组病人的ET-1水平,并与健康人比较。结果SIHTH患者血浆ET-1的水平较健康人群显著增高(P<0.05),CVS组较无CVS组显著增高(P<0.05)。结论SIHTH患者存在血管痉挛现象,血浆ET-1的水平有助于预测脑血管痉挛的发生。Objective To observe the relationship between change of Plasma endotheHn- 1 （ ET- 1 ）level and cerebral vasospasm（ CVS） on the different time in patients with secondary intraventricular hemorrhage from thalamic hemorrhage （SIHTH）. Methods 23 cases with SIHTH were divided into CVS group and control group with no CVS, CVS was judged by transcranial dopple（TCD）. ET - 1 level was measured by radio - immunity, ET - 1 in the 2 groups was compared. All the patients＇ ET - 1 was compared with normal healthy people. Results ET - I level in the patients with SIHTH was significantly higher than healthy people （ P 〈 0.05 }, and CVS group was significantly higher than control group with no CVS （ P 〈 0.05 ）. Condusion It has the phenomenon of vasospasm in patient with SIHSAH,ET - 1 maybe can predict the occurrence of CVS.

关 键 词：丘脑出血 脑室出血:内皮素-1 脑血管痉挛 

分 类 号：R743[医药卫生—神经病学与精神病学]