6-碘取代的白杨素衍生物合成及其抗癌活性  

Synthesis and Anticancer Activities of 6-Iodo-Chrysin Derivatives

作　　者：郑兴[1] 刘毅[1] 许雪梅[1] 罗星[1] 王小平[1] 杜青梅[2] 廖端芳[1] 

机构地区：[1]南华大学药理教研室,湖南衡阳421001 [2]南华大学科研兴趣小组

出　　处：《南华大学学报（医学版）》2010年第2期200-202,共3页Journal of Nanhua University(Medical Edition)

基　　金：国家教育部重点项目(20809);湖南省自然科学基金(07JJ6157)资助

摘　　要：目的研究6-碘取代白杨素衍生物的体外抗癌活性。方法合成6-碘取代的白杨素衍生物．并通过MTT法检测其对人急性粒细胞性白血病（HL-60）细胞、人结肠癌（HT-29）细胞和人胃癌（SGC-7901）细胞增殖的抑制作用。结果合成了2个6-碘取代白杨素衍生物。结论6-碘取代白杨素衍生物具有良好的抗癌活性（IC50=1．87—6．09μmol／L）。Objective To study the antieancer activity of 6 -iodo -chrysin derivatives. Methods 6 -Iodo - ehrysin derivatives were prepared and their antieaneer activities in vitro were evaluated by the standard MTT method. Restilts Two 6 - iodo - chrysin derivatives were synthesized. Conclusion 6 - Iodo - chrysin derivatives possessed the potent anticaneer activity （ IC50 = 1.87 - 6.09 μmol/L）.

关 键 词：白杨素 衍生物 碘代 抗癌活性 

分 类 号：R978.7[医药卫生—药品]