乳腺癌患者术后血清铁蛋白检测的临床价值  

The clinical values of serum ferritin detection in prediction post-operative recurrent and metastatic breast cancer

作　　者：刘露[1] 张木坤[1] 余小青[1] 张逸[1] 

机构地区：[1]广东省农垦中心医院检验科,广东湛江524002

出　　处：《右江民族医学院学报》2010年第2期136-137,共2页Journal of Youjiang Medical University for Nationalities

摘　　要：目的探讨血清铁蛋白(SF)在乳腺癌患者术后复发、转移的临床价值。方法采用放射免疫测定法(RIA)对132例乳腺癌术后患者、50例正常人进行SF测定。结果乳腺癌术后未复发组SF含量为(79±63)μg/L,与正常对照组(69±65)μg/L相比差异无显著性(P>0.05),术后复发局部转移组及术后复发局部伴内脏/骨转移组SF含量分别为(183±156)μg/L和(312±155)μg/L,与正常对照组相比差异有高度显著性(P<0.01),提示乳腺癌患者病情越接近晚期,SF含量越高。结论SF测定对乳腺癌术后复发和转移的监测、病情观察、疗效判断有一定的临床价值,是监测疗效、评估预后的重要指标。Objective To assess clinical values of serum ferritin （SF） in evaluating the severity of post- operative recurrence and metastasis in patients with breast carcinoma. Methods The radioimmunoassay was used to deteet the levels of post - operative SF in 132 patients with brest carcinoma and the SF in 50 healthy women. Results SF in non- relapse group was （79 ± 63）μg/L,compared with healthy women group （69 ± 65）μg/L, there was no statistically significant difference （ P 〉 0.05 ）. SF in post- operative relapse associated with regional metastasis group and in post - operative relapse associated internal organs/bone metastasis group was （183 ± 156）μg/L and （312 ±155）μg/L, respectively, compared with healthy women group, there were stastically significant differences （ P〈0.01）, and it suggested the more advanced stage the illness was, the higher level the SF was. Conclusion SF test has a clinic value for the observation of postoperative recurrence and metastasis, and it is an important marker of evaluating efficacy and prediction prognosis.

关 键 词：乳腺肿瘤 铁蛋白 放射免疫测定 

分 类 号：R737.902[医药卫生—肿瘤]