冰片对灯盏花素鼻腔给药在大鼠体内药动学的影响  

Effects of Borneol on the Pharmackinetics of Scutellarin after Intranasal Administration in Rats

作　　者：石森林[1] 吴瑾瑾[1] 葛卫红[1] 张晓东[1] 徐莲英[2] 

机构地区：[1]浙江中医药大学药学院,杭州310053 [2]上海中医药大学中药学院

出　　处：《浙江中医药大学学报》2010年第2期148-150,共3页Journal of Zhejiang Chinese Medical University

基　　金：国家中医药管理局项目(No:06-07ZP24);浙江省科技攻关项目(No:2003C33017)~~

摘　　要：[目的]观察冰片对灯盏花素鼻腔给药在大鼠体内药动学的影响。[方法]采用125I标记法测定SD大鼠尾静脉注射、经鼻给药、经鼻给药(加1%冰片)0.4mg/kg灯盏花索后不同时间血浆中灯盏乙素的浓度,3P87软件计算药动学参数。[结果]鼻腔给药组Tmax、Cmax分别为25.0min、0.55ug/ml,经鼻给药(加冰片)组Tmax、Cmax分别为46.5min、0.50ug/ml;鼻腔给药绝对生物利用度为53.70%,而鼻腔给药(加冰片)为52.86%,两者相比,无统计学意义。[结论]冰片延长了灯盏花素鼻腔给药在大鼠血浆中灯盏乙素的达峰时间,但对AUC基本无影响。[Objective]To observe the effects of borneol on the pharmackinetics of scutellarin after intranasal administration in rats.[Method]The different time of plasma scutellarin concentration was determined by the method of 125I label after iv injection or intranasal administration,intranasal administration of scutellarin（combined with 1% borneol）0.4 mg·kg^-1 in SD rats.To calculate the pharmacokinetic parameters by 3P87 software.[Result]The time of maximum concentration（Tmax）and the maximum concentration（Cmax）at the class of intranasal administration is 25.0 min,0.55ug/ml,at the class of intranasal administration（combined with borneol）46.5 min,0.50ug/ml;the absolute bioavailability of intranasal administration is 53.70%,while the intranasal administration（combined withborneol）is 52.86%,there is no statistically significant differences compared with each other.[Conclusion]The borneol prolongs the peak time of plasma scutellarin concentration after intranasal administration in rats,but AUC is not influenced.

关 键 词：灯盏花素 鼻腔给药 冰片 药动学 

分 类 号：R285.5[医药卫生—中药学]