动态测定阿魏酸CO_2超临界萃取溶解度及缔合模型关联  

Solubility of Ferulic Acid in the CO_2 Supercritical Fluid Determined by Dynamic Method and Correlation of Association Model

作　　者：高瑞英[1,2,3] 傅中[1] 李震 张秀宇[1] 

机构地区：[1]广东食品药品职业学院化妆品科学系,广东广州510520 [2]广东省中药研究所,广东广州510520 [3]华南理工大学环境科学与工程学院,广东广州510006

出　　处：《安徽农业科学》2010年第11期5848-5850,共3页Journal of Anhui Agricultural Sciences

基　　金：广东省中医药管理局项目(2007161;2009277);广药职院项目(2008Z011)

摘　　要：[目的]研究阿魏酸在超临界CO2流体中的溶解特性和规律。[方法]阿魏酸在超临界CO2中的溶解度采用动态法测定,HPLC法定量,对溶解度模型Chrastil方程和del Valle-Aguilera修正方程中的计算参数进行关联。[结果]在压力10.0～30.0MPa,温度313.15～343.15K下,阿魏酸的溶解度摩尔分数在10-6～10-4,Chrastil方程AARD为15.185%,del Valle-Aguilera修正方程AARD为7.003%。[结论]修正后的溶解度模型具有较好的关联精度。[Objective] The Solubility of Ferulic acid in supercritical carbon dioxide and its variation regulations were studied.[Method]The solubility of ferulic acid in supercritical carbon dioxide was determined by dynamic method,and quantified by HPLC.Chrastil model and del Valle-Aguilera modified model were proposed to correlate and predict solubility in supercritical fluid.[Result] Under the conditions of 10.0-30.0 MPa and 313.15-343.15 K,the mol fractions of the ferulic acid solubility were from 10^-6 to 10^-4.The AARD were 15.18% for Chrastil model and 7.003% for del Valle-Aguilera modified model.[Conclusion] The modified solubility model proved to be more valid for solubility correlation of ferulic acid.

关 键 词：阿魏酸 超临界CO2萃取 动态法 溶解度 关联 

分 类 号：TQ461[化学工程—制药化工] R284[医药卫生—中药学]