体质量对反流性食管炎患者下食管括约肌压力和24h食管pH监测结果的影响  

Effect of body weight on low esophageal sphincter pressure and 24-hour esophageal pH monitoring in patients with reflux esophagitis

作　　者：吴萍[1] 许树长[2] 舒晓亮[1] 陈莹[2] 王琛[1] 姚莉雯[1] 

机构地区：[1]同济大学附属同济医院临床营养科,200065 [2]同济大学附属同济医院消化科,200065

出　　处：《中华消化内镜杂志》2010年第4期178-181,共4页Chinese Journal of Digestive Endoscopy

摘　　要：目的探讨反流性食管炎（RE）患者中，体质量对下食管括约肌压力（LESP）和24h食管pH监测结果的影响。方法对18例体质量正常RE患者和22例超重肥胖RE患者进行LESP和24h食管pH监测，对结果进行统计分析。结果超重肥胖组RE患者的LESP、pH〈4总反流时问百分比、反流时间〉5min的反流次数、总反流数、DeMeester分与体质量正常组RE患者比较，差异均有统计学意义（P均〈0．05）；而超重肥胖组RE患者与体质量正常组RE患者的下食管括约肌松弛率（LESRR）比较，差异无统计学意义（P〉0．05）。结论在RE患者中，超重肥胖可影响食管动力并增加食管的酸暴露，控制体质量对治疗RE可能有一定作用。Objective To explore the effect of body mass index （BMI） on low esophageal sphincter pressure （LESP） and 24-hour esophageal pH monitoring in patients with reflux esophagitis （RE）. Methods The results of LESP and 24-hour esophageal pH monitoring were compared between 18 RE patients with normal BMI and 22 RE patients with high BMI. Results There were significant differences between 2 groups regarding LESP, time percentage of pH 〈 4, long reflux episodes （ 〉 5 minutes）, total reflux episodes and DeMeester score （ P 〈 0. 05 ） , while there was no significant difference between 2 groups in low esophageal sphincter relaxation rate （ P 〉 0. 05 ）. Conclusion Overweight and obesity may affect esophageal motility and increase esophageal exposure to acid in RE patients, which warrents weight control in treat- ment of RE.

关 键 词：体重 食管炎 反流性 下食管括约肌压力 24H食管PH监测 

分 类 号：R571[医药卫生—消化系统]