茉莉花渣黄酮抑菌活性研究  

Antibacterial Activity Study of Flavonoids from Jasmine Sambac Slag

作　　者：韦英亮[1] 刘志平[1] 马建强[1] 崔建国[1] 

机构地区：[1]广西师范学院化学与生命科学学院,广西南宁530001

出　　处：《化工技术与开发》2010年第4期8-9,14,共3页Technology & Development of Chemical Industry

基　　金：南宁市科学研究与技术开发计划项目(20060163C)

摘　　要：采用超声波提取茉莉花渣黄酮,通过D101大孔吸附树脂进行纯化,得到茉莉花渣黄酮,并以芦丁及链霉素为对照,对茉莉花渣黄酮进行体外抗菌试验研究。结果表明茉莉花渣黄酮对普通变形杆菌、大肠杆菌、葡萄球菌和枯草芽孢杆菌有一定的抗菌作用。此外采用MTS法,研究了茉莉花渣黄酮对Sk-Hep-1(肝癌细胞株)、H-292(肺癌细胞株)、PC-3(前列腺癌细胞株)及Hey-1B(卵巢癌细胞株)体外抗肿瘤活性试验,结果表明茉莉花渣黄酮对肺癌H-292细胞株在体外具有一定的生长抑制作用,其IC50在260μg.mL-1左右。The flavonoid was extracted from Jasmine sambac slag by ultrasonic method,then was purified used D101 macroporous resin.Applied the rutin and streptomycin as contrast,the antibacterial activity of flavonoids was investigated and the results showed that the flavonoids of Jasmine sambac slag presented a certain effects on Proteus vulgaris,Escherichia coli,Staphylococcus aureus and Bacillus subtilis.In addition,the cytotoxicity of the flavonoids in vitro against sk-Hep1,H-292,PC-3 and Hey-1B cells were also investigated.The result indicated that the flavonoids of Jasmine sambac slag displayed some cytotoxicity against H-292（IC50： 260μg/mL）.

关 键 词：茉莉花渣 茉莉黄酮 抑菌活性 

分 类 号：R284.2[医药卫生—中药学]