细胞色素P450 2C19基因多态性与结直肠癌关系的对照研究  

Case-control study on the polymorphisms of cytochrome P450 2C19 and susceptibility in colorectal cancer

作　　者：胡祥鹏[1] 吴建胜[1] 吴明[1] 陈增强[2] 黄庆科[1] 马升高[1] 

机构地区：[1]温州医学院附属第一医院消化内科,浙江温州325000 [2]温州医学院附属第一医院检验科,浙江温州325000

出　　处：《中华肿瘤防治杂志》2010年第5期330-332,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：浙江省教育厅科研项目(20070988)

摘　　要：目的:研究细胞色素P4502C19(CYP2C19)基因多态性与结直肠癌发生的关系。方法:对117例结直肠癌患者和109名对照人群进行病例对照研究,采用PCR-RFLP方法检测CYP2C19基因型。结果:纯合子强代谢型(homEM)、杂合子强代谢型(hetEM)和弱代谢型(PM)分布频度在结肠癌组(38.7%、45.2%和16.1%)、直肠癌组(34.5%、52.7%和12.7%)和对照组(36.7%、44.0%和19.3%)间差异无统计学意义,P>0.05;在结肠癌和直肠癌组,PM型经性别和年龄调整后的OR值分别为0.693(95%CI:0.266～1.807,P=0.454)和0.757(95%CI:0.263～2.184,P=0.607),差异无统计学意义。结论:CYP2C19基因多态性与结直肠癌发生的危险性无直接关系。OBJECTIVE：To study the relationship between genetic polymorphism of cytochromes P450 2C19 and the susceptibility of colorectal cancer.METHODS：A case-control study was conducted with 117 cases of colorectal cancer and 109 cases of population-based controls.The genotypes were detected by PCR-RFLP.RESULTS：The frequencies of homozygous extensive metabolisers（homEM）,heterozygous extensive metabolisers（hetEM）and poor metabolisers（PM）genotypes distribution in the colonic（38.7%,45.2% and 16.1%）or rectal（34.5%,52.7% and 12.7%）cancer group were not significantly different from those of the control group（36.7%,44.0% and 19.3%,P〉0.05）.The OR adjusted by age and sex were 0.693（95%CI：0.266-1.807,P=0.454）and 0.757 respectively（95%CI：0.263-2.184,P=0.607）in the colonic or rectal cancer group without statistically significance.CONCLUSION：There is no direct relationship between genetic polymorphism of cytochromes P450 2C19 and the susceptibility of colorectal cancer.

关 键 词：结直肠肿瘤 CYP2C19 基因多态性 病例对照 

分 类 号：R735.3[医药卫生—肿瘤]