^99Tc^m奥曲肽核素显像诊断结直肠癌的研究  

Effect of ^(99)Tc^m-octreotide imaging on diagnosis of colorectal carcinoma

作　　者：吴培仁[1] 何小江[2] 许林[1] 俞浩[2] 林天胜[1] 卢传辉[1] 

机构地区：[1]福建医科大学附属厦门第一医院肿瘤外科,福建厦门361003 [2]福建医科大学附属厦门第一医院核医学科,福建厦门361003

出　　处：《中华肿瘤防治杂志》2010年第5期381-383,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：福建省厦门市卫生局重点资助项目(WSK5030)

摘　　要：目的:探讨99Tcm奥曲肽显像对结直肠癌的诊断价值。方法:30例经内窥镜检查活检病理确诊的结直肠癌及6例非结直肠癌患者,术前进行腹部的99Tcm奥曲肽显像,以99Tcm直接标记的奥曲肽进行分析。结果:99Tcm奥曲肽显像检测30例结直肠癌4例阳性,26例阴性;6例非结直肠癌2例阳性,4例阴性。99Tcm奥曲肽显像对结直肠癌诊断的敏感度、特异度和准确度分别为13.33%、33.33%和22.22%。结论:99Tcm奥曲肽显像是一种无创、安全、经济的检查方法,但对结直肠癌诊断价值有限;需要用各种亚型的生长抑素受体和扩大样本量做进一步研究,以提高诊断的准确度。OBJECTIVE：To evaluate the value of ^99Tc^m-octreotide scintigraphy in the diagnosis for colorectal carcinoma.METHODS：30 patients with colorectal carcinoma and 6 patients with non-colorectal carcinoma were affirmed for examining biopsy pathology of peephole.Before operation ^99Tc^m-octreotide scintigraphy imaging of abdomen were carried on.Octreotide of ^99Tc^m direct sign carry on analysis.RESULTS：4 were examined the positive and 26 negative of 30 patients with colorectal carcinoma,2 cases were examined the positive and 4 negative 6 patients with non-colorectal carcinoma,it examined for ^99Tc^m-octreotide scintigraphy The sensitivity,specificity and accuracy of ^99Tc^m-octreotide scintigraphy in the diagnosis for colorectal carcinoma were 13.33%,33.33%,22.22%.CONCLUSION：^99Tc^m-octreotide scintigraphy is a promising noninvasive imaging technique but of limited value in the diagnosis for colorectal carcinoma,need further studing for somatostatin receptors of types and enlarging samples and increase accuracy of diagnose.

关 键 词：结直肠肿瘤 受体 生长抑素 奥曲肽 放射性核素显像 诊断 

分 类 号：R735.37[医药卫生—肿瘤]