苯那普利与氟伐他汀单用及联用对阿霉素肾病大鼠血清脂联素的影响  

Influence of Benazepril and Fluvastatin on Adiponectin in Adriamycin-Induced Nephrotic Rats

作　　者：张道友[1] 崔明春[1] 吴小冬[1] 杨利才[1] 杨沿浪[1] 徐海红[1] 

机构地区：[1]皖南医学院附属弋矶山医院肾内科,安徽省芜湖市241001

出　　处：《中国动脉硬化杂志》2010年第1期29-32,共4页Chinese Journal of Arteriosclerosis

基　　金：安徽省学术技术带头人科学研究基金(2002HBL25)

摘　　要：目的探讨苯那普利与氟伐他汀单用及联用对阿霉素肾病大鼠脂联素的影响。方法雄性SD大鼠120只,适应性饲养2周后,随机抽取18只为正常对照组,另外102只制作阿霉素肾病模型。84只造模成功大鼠随机分为四组:模型组(等容积生理盐水,n=21)、苯那普利组[苯那普利3.5mg/(kg.d),n=21],氟伐他汀组[氟伐他汀10mg/(kg.d),n=21]和苯那普利与氟伐他汀联合治疗组[苯那普利3.5mg/(kg.d)+氟伐他汀10mg/(kg.d),n=21]。分别于2、6及10周末,遵循随机化原则,按n=6分层抽取各组样本,收集24h尿液、血液标本待测。结果与模型组相比,苯那普利组、氟伐他汀组及联合治疗组血清甘油三酯、总胆固醇、脂联素浓度均降低,24h尿蛋白减少;联合治疗组更为明显;相关分析表明,蛋白尿、甘油三酯和总胆固醇分别与血脂联素浓度呈明显正相关关系(P<0.01)。结论苯那普利与氟伐他汀可减轻阿霉素肾病大鼠蛋白尿、降低血清甘油三酯、总胆固醇及脂联素浓度,联用时疗效更明显。提示苯那普利与氟伐他汀至少部分通过降低脂联素水平而减轻肾脏损害。Aim To investigate the influence of benazepril alone and in combination with fluvastatin on adiponectin（APN）in adriamycin（ADR）-induced nephrotic rat models.Methods Male Sprague-Dawley（SD）rats were randomly seperated into five groups and given different therapies.Normal control group（n=18）.Nephrotic model was induced by tail introvenously injection of ADR（6.0 mg/kg）.Eighty-four ADR-induced nephrotic male SD rats were randomly seperated into 4 groups：without treatment group（normal saline 3 mL/d;n=21）,benazepril treatment group（benazepril 3.5 mg/（kg·d）;n=21）,fluvastatin treatment group（fluvastatin 10 mg/（kg·d）;n=21）and combined treatment group（benazepril 3.5 mg/（kg·d）plus fluvastatin 10 mg/（kg·d）,n=21）.After the end of therapies for 2,6 and 10 weeks,the samples of 24 h urine,serum were collected and assayed（six rats were assigned randomly in every group）.Results Compared with normal control group,24 h urinary protein excretion,the serium levels of total cholesterol,triglyceride and APN were increased significantly in the other four groups（P0.01）.Treatment with either benazepril or fluvastatin or combined with benazepril and fluvastatin could reduce 24 h urinary protein excretion,reduce the serium levels of total cholesterol,triglyceride and APN（P0.05 or P0.01）,especially for combined treatment group.Proteinuria,total cholesterol,triglyceride were correlated with APN（P0.01）.Conclusions Benazepril and fluvastatin can decrease proteinuria,reducse serium triglyceride,total cholesterol and APN in ADR-induced nephrotic rats.Combination of benazepril and fluvastatin has superiority over monotherapies on renal protection.These results suggest that benazepril and fluvastatin may mediated through,at least partly,decreasing serum APN and attenuating renal damage.

关 键 词：阿霉素肾病 苯那普利 氟伐他汀 脂联素 

分 类 号：R36[医药卫生—病理学]