外周血内皮祖细胞水平与肝癌肝动-门静脉瘘的相关性  

Relevance between peripheral endothelial progenitor cells and hepatic artery-portal vein shunting in primary hepatic carcinoma

作　　者：布学慧[1] 郑昭敏[1] 杜文军[1] 刘靓雯[1] 陈士俊[1] 

机构地区：[1]山东大学济南市传染病医院介入科,济南250021

出　　处：《山东大学学报（医学版）》2010年第4期87-90,共4页Journal of Shandong University:Health Sciences

基　　金：济南市卫生局科技项目(2008-01)

摘　　要：目的探讨外周血内皮祖细胞(EPC)水平与原发性肝癌肝动-门静脉瘘(HA-PVS)形成的相关性。方法用流式细胞术测定20例健康对照组,22例慢性乙型肝炎组,30例无HA-PVS的肝癌组,28例有HA-PVS的肝癌组患者外周血EPC的水平。结果有瘘肝癌组患者外周血EPC占淋巴细胞的比例为(21.09±2.79)‰,无瘘肝癌组(12.72±3.05)‰,慢性乙型肝炎组(3.53±2.11)‰,健康对照组(2.98±2.64)‰。与健康对照组和慢乙肝组比较,两肝癌组EPC水平均升高,差异均有统计学意义(P<0.01)。有瘘肝癌组中,EPC升高更明显(P<0.01),块状型肝癌、自发性细菌性腹膜炎和门脉栓塞的发生率高,均与无瘘肝癌组存在统计学意义(P=0.031,P=0.036,P=0.044)。结论外周血EPC水平与原发性肝癌HA-PVS的形成有关,并能反映肝癌的类型、转移和预后。Objective To study the relevance between the level of peripheral endothelial progenitor cells（EPCs）and hepatic artery-portal vein shunting（HA-PVS）in primary hepatic carcinoma（PHC）. Methods The level of EPCs was detected by flow cytometry in 20 healthy controls,22 chronic hepatitis B,30 PHC without HA-PVS and 28 PHC with HA-PVS. Results The proportion of EPCs in the peripheral lymphocytes was （21. 09 ± 2. 79）‰,（12. 72 ± 3. 05）‰, （3. 53 ±2. 11）‰ and （2. 98 ±2. 64）‰ in PHC with HA-PVS,PHC without HA-PVS,the chronic hepatitis B and the healthy controls respectively. In the two cancer groups,the proportion of EPCs were significantly higher than that in the chronic hepatitis B group and in the healthy control （P〈0. 01）. Compared with the PHC group without HA-PVS,the proportion of EPCs in the PHC group with HA-PVS was significantly higher （P〈0. 01）. The rates of massive-liver cancer,spontaneous peritonitis and portal thrombosis were higher in the cancer group with HA-PVS,compared that in the cancer group without HA-PVS（P〈0. 01,P = 0. 031,P = 0. 036,P = 0. 044）. Conclusions The level of EPC in peripheral blood is correlated with the formation of HA-PVS in PHC. Expression of EPC in peripheral blood may reflect the clinical features of PHC on type,metastasis and prognosis.

关 键 词：内皮祖细胞 肝肿瘤 肝动门静脉瘘 流式细胞术 

分 类 号：R735.7[医药卫生—肿瘤]