胃癌发生过程中细胞膜磷脂变化的研究  

Variations of cellular membrane phospholipids with genesis of gastric cancer

作　　者：张佳[1] 叶尔买克[1] 王健生[1] 吴文安[1] 王嗣岑[2] 张明鑫[1] 周苏娜[1] 

机构地区：[1]西安交通大学医学院第一附属医院肿瘤外科,陕西西安710061 [2]西安交通大学医学院药物研究所,陕西西安710061

出　　处：《现代肿瘤医学》2010年第5期855-857,共3页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:30600744)

摘　　要：目的:检测胃癌原发灶及癌旁黏膜组织细胞膜磷脂含量,探讨其与胃癌发生的关系。方法:采用高效液相色谱法检测胃癌原发灶及癌旁黏膜组织细胞膜PI、PS、PE和PC的含量。结果:30例胃癌患者中原发灶和癌旁黏膜组织中细胞不同膜磷脂的含量(mg/g):PI为1.69±0.09和1.18±0.10;PS为0.55±0.04和0.54±0.04;PE为52.57±5.58和27.54±3.36;PC为121.36±6.49和62.90±5.02。癌与癌旁黏膜组织中PS的含量差异无显著性意义(P>0.05)。结论:胃癌发生过程中胃癌原发灶中PI、PE、PC含量高于癌旁黏膜组织(P<0.01)。胃癌原发灶与癌细胞膜磷脂发生了明显变化,PI、PE、PC增高与胃癌发生有关。Objective： To detect membrane phospholipids and study the relationship of membrane phospholipids with genesis of gastric cancer. Methods： Membrane phospholipids of PI, PS, PE, and PC were detect with high per- formance liquid chromatography. Results： In primary loci and paratumor gastric mucosa of 30 cases, the content of PI were （rag/g） ： 1.69 ± 0.09,1.18 ±0. 10 respectively, PS 0.55 ± 0.04,0.54 ± 0.04 respectively, PE 52.57 ± 5.58, 27.54 ± 3.36 respectively, and PC 121.36 ± 6. 49 , 62. 90 ± 5.02 respectively. The contents of PI , PE and PC were higher in primary foci than in paratumor mucosa（ P 〈 0.01 ）. PS in primary loci and paratumor gastric mucosa was not significantly different（ P 〉 0.05 ）. Conclusion： Membrane phospholipids have obvious variations in genesis of gastric cancer. Rises of PI, PE and PC were associated with genesis of gastric cancer.

关 键 词：胃癌 细胞膜 膜磷脂 

分 类 号：R730.21[医药卫生—肿瘤] R735.2[医药卫生—临床医学]