乳腺癌组织中PCNA和Cath-D的表达及相关性研究  

expression and correlation of Cath-D,PCNA in breast carcinoma

作　　者：谢小卫[1,2] 杜红文[1] 孙兴旺[1] 李勤 李涛 

机构地区：[1]西安交通大学第一附属医院影像中心,陕西西安710061 [2]陕西省肿瘤医院,陕西西安710061

出　　处：《现代肿瘤医学》2010年第5期903-905,共3页Journal of Modern Oncology

基　　金：陕西省卫生厅科研基金资助项目(编号:06c08)

摘　　要：目的:探讨Cath-D、PCNA在乳腺癌中表达的意义及相关性。方法:应用免疫组化S-P法检测49例乳腺癌中Cath-D、PCNA的表达情况,并与35例乳腺良性病变进行对照分析。结果:乳腺良性病变Cath-D、PCNA的阳性率分别为17.1%(6/35)、28.6%(10/35)。乳腺癌Cath-D、PCNA的阳性率分别为53%(26/49)、73.5%(36/49),差异具有统计学意义(P<0.05)。乳腺癌Cath-D的表达与年龄无关(P>0.05),与组织学分级相关(P<0.05);PCNA的表达与年龄、组织学分级均无关(P>0.05)。乳腺癌Cath-D、PCNA的表达呈正相关(P<0.05)。结论:Cath-D、PCNA表达异常在乳腺癌的发生、发展中具有重要的作用,两者具有相互作用。Cath-D、PCNA可用于良、恶性乳腺疾病的鉴别,对乳腺良性病变的恶性转化有一定的预兆性。Objective：To study the expressions and correlation of Cath - D and PCNA in breast carcinomas. Methods ： The expressions of Cath - D and PCNA were studied in 49 cases of breast carcinoma by immumohistoehem- ical technology ,35 cases of benign lesions served as control. Results：Positive rates of Cath- D , PCNA in breast be- nign lesions were 17.1% （6/35 ） ,28.6 % （ t0/35 ） respectively. Positive rates of Cath - D ,PCNA in breast carci- nomas were 53 % （26/49） ,73.5 % （36/49） ,respectively. Positive rates of Catb - D,PCNA in breast benign le- sions and in breast carcinomas had significant difference （ P 〈 0.05 ） . The expression of Cath - D in breast carcino- mas did not correlate with age （ P 〉 0.05 ） . But expression of Cath - D in breast carcinomas was associated wit h hi- tological grading （ P 〈 0.05 ） , the expression of PCNA in breast carcinomas did not correlate with age , histological grading （ P 〉 0.05 ） . There was a positive correlation between the expressions of p27 and PCNA in breast carcinomas （ P 〈 0.05 ）. Conclusion： Abnormal expression of Cath - D , PCNA play an important role initiation and development of breast carcinomas. Cath - D , PCNA interact with one another in breast carcinomas. Catb - D,PCNA can be used to identify benign and malignant breast disease. There is some significance of prediction as malignant change of breast benign lesions.

关 键 词：乳腺癌 Cath—D PCNA 

分 类 号：R737.9[医药卫生—肿瘤]