新型抗癌药埃坡霉素类似物联合卡培他滨治疗晚期乳腺癌的临床疗效观察  

Epothilone B Analogue (BMS-247550) combined with capecitabine in the treatment of advanced breast cancer

作　　者：薛妍[1] 斯晓明[1] 杨静悦[1] 陈衍[1] 尤向辉[1] 刘文超[1] 

机构地区：[1]第四军医大学西京医院肿瘤科,陕西西安710032

出　　处：《现代肿瘤医学》2010年第5期920-923,共4页Journal of Modern Oncology

摘　　要：目的:观察埃坡霉素类似物(BMS-247550)联合卡培他滨治疗晚期乳腺癌的疗效与安全性。方法:2005年12月至2007年6月,以埃坡霉素类似物联合卡培他滨治疗晚期乳腺癌12例。埃坡霉素类似物40mg/m2,静滴,持续3h以上,第1天;卡培他滨1000mg/m2,口服,2次/日,连用14天,21天为1周期。本组中位化疗周期数为6个(2-10周期)。结果:12例均可评价疗效及不良反应。完全缓解(CR)0例(0%),部分缓解(PR)8例(66.7%),稳定(SD)4例(33.3%),进展(PD)0例(0%),总有效率(CR+PR)66.7%。中位肿瘤进展时间(TTP)6.5个月,1年生存率75.0%。主要毒性为骨髓抑制、黏膜炎、腹泻、恶心、呕吐、便秘、手足综合征、神经毒性。结论:埃坡霉素类似物和卡培他滨联合方案治疗晚期乳腺癌的疗效较好,使用方便,毒性反应可以耐受,是晚期乳腺癌的有效解救治疗方案。Obiective：To evaluate the efficacy and safety of combination chemotherapy of Epothilone B Analogue （ BMS - 247550） combined with capecitabine for advanced breast cancer （ABC）. Methods： From December 2005 to June 2007,12 patients with advanced breast cancer （ABC） were treated with combination chemotherapy of Epothilone B Analogue and eapecitabine. Epothilone B Analogue dOmg/m2 was used for more than 3 hours on day 1 every three weeks ,and capecitabine 1000mg/m2 was used twice per day on day 1 - 14 every three weeks. The median number of cycles was 6 （range：2- 10 cycles）. Results： Response rates and side effects could be evaluated in all 12 patients. The overall response rate was 66.7% with a median time to progression of 6.5 months. One - year survival rate was 75.0%. The main side effects were hematologic and gastrointestinal toxieities, including grade 3 to 4 leukopenia in 10 patients （83.4%） ,neutropenia in 10 patients （83.4%） ,platelets reduction in 2 patients （16.7%）, and grade 3 to 4 mucositis in 2 patients （16.7%） ,diarrhea in 1 patient （8.3%） ,nausea and vomiting in 1 patient （8.3%） ,con- stipation in 1 patient （8.3%） ,as well as grade 3 to 4 hand and foot symdrome in 1 patient （8.3%） ,neurotoxicity in 1 patient （8.3%）. Condusion：Epothilone B Analogue and capecitabine combination is active in the treatment of advanced breast cancer patient with an acceptable toxicity, and may be a therapeutic alternative for advanced breast cancer.

关 键 词：埃坡霉素类似物 卡培他滨 联合化疗 晚期乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]