肿瘤抑制基因PTEN研究新进展  

Research progress of tumor suppressor gene PTEN

作　　者：李季林[1] 肖建[1] 于如同[2] 

机构地区：[1]复旦大学附属中山医院青浦分院,上海201700 [2]徐州医学院附属医院神经外科,江苏徐州221002

出　　处：《现代肿瘤医学》2010年第5期1034-1037,共4页Journal of Modern Oncology

摘　　要：PTEN是具有磷酸酶活性的抑癌基因,其低表达或缺失与肿瘤的进展及不良预后密切相关,其抑制肿瘤作用机制系通过抑制PI3K/AKT信号通路,FAK/PI30C和MAPK信号通路,FRAP/mTOR信号通路及影响核转录因子-kB/IB信号通路;另外,NEDD4-1通过泛素化蛋白体降解途径调节PTEN,BMP通过RAS/ERK信号通路抑制PTEN表达,IGF-1通过IGF-1/PI3K/Akt信号通路调节PTEN。PTEN is a tumor suppressor gene of phosphatased activity. Its low or lacking expression closely relate with tumor progress and poor prognosis. Its mechanism of inhibiting the tumor is through inhibiting the PI3K/AKT signaling pathway, FAK/PI30C and MAPK signaling pathway, FRAP / mTOR signaling pathway and impacting of the nuclear transcription factor signaling pathway - kB/IB ; In addition, NEDIM - 1 regulates PTEN through the ubiquitin protein degradating pathway, BMP inhibit the expression of PTEN through the RAS/ERK signaling pathway. IGF - 1 regulates PTEN through IGF - 1/PI3K/Akt signaling pathway.

关 键 词：PTEN PI3K NEDD4-1 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]