兔肝MR灌注表现的实验研究  

An Experimental Study on MR Perfusion Imaging in Rabbit Liver

作　　者：范义[1] 刘静华[1] 梁冰[1] 刘哲辉[1] 李泳[1] 娄明武[1] 

机构地区：[1]深圳市龙岗中心医院介入影像科,广东深圳518116

出　　处：《实用放射学杂志》2010年第4期575-577,605,共4页Journal of Practical Radiology

基　　金：广东省科技计划项目（编号：93100）.

摘　　要：目的探讨兔正常肝脏的MR灌注特征。方法新西兰大白兔10只，体重2．5～3．0kg，分别进行MR灌注成像。采用TFE序列。灌注成像参数：矩阵89×256，TR4．3ms，TE1．4ms，激励次数1，视野355mm×75mm，层厚5mm，间距1mm，NSA为1次。扫描层面数4层，每层反复激励65次，总扫描时间为1min 20s。将原始图像输入到PHILIPS后处理工作站（VIEWFORUM），自动生成MR灌注图。分析MR灌注图像及不同组织MR灌注成像特点。结果肝血容量（HBV）图、肝血流量（HBF）图清楚勾画出肝脏轮廓。腹主动脉强化曲线，表现为速升速降，MR信号强度峰值496±131，肝静脉表现为逐渐升高，MR信号强度峰值323±92，强化时间比腹主动脉晚。正常肝组织强化曲线，呈缓慢升降，MR信号强度峰值194±58。腹主动脉、肝静脉及正常肝组织MR信号强度峰值的比较有统计学差异（F=10．27，P=0．012）。结论采用TFE序列可成功进行兔MR灌注成像，HBV图、HBF图清楚勾画出肝脏轮廓，强化曲线可初步反映兔肝脏不同组织的血流情况。Objective To explore MR perfusion imaging characteristics of rabbit liver. Methods MR perfusion imaging was performed in 10 New Zealand rabbits（weight：2.5 × 3.0 kg） respectively. The MR perfusion imaging protocol consisted of T1- weighted fast field echo（FFE） sequences with a field of view of 355 mm×75 mm,matrix 89×256, TR/TE of 4.3/1.4 millisecond,slice thick ness of 5 ram,intersection gap of 1 mm,NSA of 1. This sequence was repeated 65 times,in 4 slices （in totai,80 seconds）. The original data were transmitted to PHILIPS workstation and formed MR perfusion images automatically. The MR perfusion images in different liver tissues were observed and analyzed. Results The rabbit liver profiles were depicted on hepatic blood flow（HBF） and hepatic blood volume（HBV） images. Time--intensity curves derived from ROIs drawn in abdominal aorta appeared as a type of rapid increase and decrease,gradually increase in hepatic vein and slowly increase and decrease in normal liver tissues. The peak of MR sig hal intensity of abdominal aorta,hepatic vein and normal liver tissues were 496±131,323±92,194±58 separately. Conelnsion MR perfusion imaging can be performed for rabbit liver successfully by using MR TFE series. The rabbit liver profiles are depicted by HBF and HBV images. The hemodynamics of different liver tissues can be responded by time--intensity curves preliminarily.

关 键 词：兔 肝脏 磁共振灌注成像 实验研究 

分 类 号：R-332[医药卫生] R322.47