显微手术切除联合瘤腔植入缓释氟尿嘧啶和^(125)I治疗胶质瘤的临床观察  

Treatment of malignant intracranial neoplasms by surgical excision conbined with the chemotherapy of intraccerebral implantation of 5-FU biodegradable polymer and radiochemotherapy with interstitial implantation of 125I

作　　者：袁绍纪[1] 吕学明[1] 李际文[2] 张荣伟[1] 刘子生[1] 孙希炎[1] 卢培刚[1] 朱伟杰[1] 吕福林[1] 

机构地区：[1]济南军区总医院神经外科全军神经外科专科中心,山东济南250031 [2]章丘市人民医院神经外科,山东章丘250200

出　　处：《中华肿瘤防治杂志》2010年第1期62-64,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨外科显微手术切除联合瘤床内植入5-氟尿嘧啶(5-FU)多聚缓释体局部化疗和125I局部放疗治疗胶质瘤的疗效。方法:65例胶质瘤行开颅显微手术切除,术中瘤床周围植入5-FU多聚缓释体和125I粒子,术后每3个月立体定向引导再次植入1～2次。观察疗效和瘤周水肿情况及不良反应。结果:术后1周内头痛明显,脑脊液白细胞不同程度的升高,瘤周水肿较单纯手术明显,经治疗所有患者都顺利出院。随访6个月～5年,39例患者获完全随访;患者生存36例。结论:手术切除肿瘤联合瘤床内植入缓释5-FU多聚缓释体局部化疗和125I局部放疗,是治疗胶质瘤的一种有效地方法。OBJECTIVE：To investigate the effectiveness of treatment of malignant intracranial neoplasms by surgical excision conbined with the chemotherapy of intraccerebral implantation of 5-FU biodegradable polymers and radiochemotherapy with interstitial implantation of 125I. METHODS：In 15 patients with malignant intracranial neoplasms,the tumor was surgically removed and 5-FU biodegradable polymers and 125I seeds were implanted during operation in the tumor bed and postoperation. The patients were implanted for 1-2 times 3 months after operation. The patients were followed up for 6-24 months to observe the effects,surrounding cerebral edema and side-effects. RESULTS：Following up 6-60 months and 39 patients were finished. Thirty-six patients survived. The headache and surrounding cerebral edema was significant,and WBC was high. CONCLUSION：The treatment of malignan intracranial neoplasms by surgical excision conbined with the chemotherapy of intraccerebral implantation of 5-FU biodegradable polymers and radiochemotherapy with interstitial implantation of 125I is an effective and safe methods.

关 键 词：神经胶质瘤/外科学 神经胶质瘤/药物疗法 药物植入物 碘放射性同位素 

分 类 号：R739.4[医药卫生—肿瘤] R730.264[医药卫生—临床医学]