^(131)Ⅰ治疗分化型甲状腺癌颈部软组织转移的临床分析  

Clinical analysis of cervical soft tissue metastasis of differentiated thyroid cancer with ^(131)Ⅰ treatment

作　　者：王强[1] 余永利[1] 高秀丽[1] 

机构地区：[1]上海交通大学第六人民医院核医学科,上海200233

出　　处：《临床肿瘤学杂志》2010年第4期362-364,共3页Chinese Clinical Oncology

摘　　要：目的分析分化型甲状腺癌(DTC)术后患者颈部软组织转移特点及大剂量131Ⅰ治疗效果。方法回顾1997年至2008年在本科接受131Ⅰ治疗的856例DTC术后患者,其中23例(2.7%)合并颈部软组织转移灶。结果23例颈部软组织转移与833例无颈部软组织转移患者存在远处转移的比例分别为47.8%和26.9%(P<0.05);大剂量131Ⅰ治疗颈部软组织转移治愈率、有效率和无效率分别为39.2%、56.5%和4.3%;单纯颈部软组织转移与合并远处转移患者颈部软组织转移灶治愈率、有效率、无效率分别为48.3%、51.7%、0和18.2%、72.7%、9.1%(P>0.05)。结论DTC术后颈部软组织转移合并远处转移的可能性较高;大剂量131Ⅰ治疗颈部软组织转移疗效显著。Objective To analyze the characteristics of cervical soft tissue metastasis in postoperative of differentiated thyroid cancer and the effect of high dose 131Ⅰ treatment.Methods There were 856 patients in postoperative of DTC received 131Ⅰ treatment from 1997 to 2008 in our sections,of which 23 cases（2.7%）combined with cervical soft tissue metastasis.Results The percentage of distant metastasis in 23 cases with cervical soft tissue metastasis and 833 cases with non-existence were 47.8% and 26.9%（P0.05）.The cure rate,effective rate and ineffective rate of cervical soft tissue metastasis with high does 131Ⅰ treatment were 39.2%,56.5% and 4.3%.The cure rate,effective rate and ineffective rate of simple cervical soft tissue metastasis and cervical soft tissue metastasis combined with distant metastasis were 48.3%,51.7%,0 and 18.2%,72.7%,9.1%（P0.05）.Conclusion Cervical soft tissue metastasis in postoperative of DTC usually combined with distant metastasis.High dosage of 131Ⅰ therapy has rather powful effects on cervical soft tissue metastasis in postoperative of DTC.

关 键 词：甲状腺肿瘤 碘放射性同位素 放射疗法 肿瘤转移 

分 类 号：R730.55[医药卫生—肿瘤] R736.1[医药卫生—临床医学]