埃索美拉唑为基础的三联一线治疗幽门螺杆菌的疗效  

Efficacy of esomeprazole-based triple therapy for Helicobacter pylori infection

作　　者：李玉琴[1] 仇玉平[1] 潘晓林[1] 姚林华[1] 马士杰[1] 张国新[1] 

机构地区：[1]南京医科大学第一附属医院消化病科,210029

出　　处：《江苏医药》2010年第6期634-635,共2页Jiangsu Medical Journal

基　　金：江苏省科教兴卫重点人才基金资助(RC2007047)

摘　　要：目的观察埃索美拉唑联合左氧氟沙星和阿莫西林一线治疗幽门螺杆菌的疗效。方法163例幽门螺杆菌阳性患者,随机分为3组,分别应用埃索美拉唑20mg每日2次(A组),埃索美拉唑40mg每日2次(B组),埃索美拉唑40mg每日1次(C组),3组均加用左氧氟沙星500mg每日1次和阿莫西林1000mg每日2次,疗程7d。并且对幽门螺杆菌根除率分别按意愿治疗(ITT)分析和方案(PP)分析进行评估。结果A、B、C组各治疗方案的根除率:ITT法为82.98%、87.10%、70.37%;PP法为86.67%、88.52%、73.08%。B组明显高于C组(P<0.05)。结论埃索美拉唑联合左氧氟沙星和阿莫西林一线治疗能显著提高幽门螺杆菌根除率。Objective To observe the efficacy of esomeprazole-based triple therapy as the first-line treatment for Helicobacter pylori infection.Methods A total of 163 patients with helicobacter pylori infection confirmed by rapid urease test and 13C breath test was randomly divided into there groups.Esomeprazole 20 mg bid （group A）,40 mg bid（group B） or 40 mg qd （group C） was used,which was combined with levofloxacin 500 mg qd and amoxicillin 1000 mg bid for 1 week.The eradication rates of Helicobacter pylori infection were tested with the methods of ITT and PP.ResultsThe eradication rates for groups of A,B and C were 82.98%,87.10% and 70.37% by ITT analysis,and were 86.67%,88.52% and 73.08% by PP analysis,respectively.The eradicaton rates of group B were higher than those of group C（P0.05）.Conclusion Esomeprazole-based triple therapy as the first-line drugs for Helicobacter pylori infection can effectively improve the eradication rate.

关 键 词：埃索美拉唑 左氧氟沙星 幽门螺杆菌 

分 类 号：R573[医药卫生—消化系统]