尿钠排泄量与动脉弹性指数的关系  

Relationship between Urinary Sodium Excretion and Arterial Compliance

作　　者：张海锋[1] 李新立[1] 周艳丽[1] 朱桢燕[1] 徐芳[1] 李静[1] 曹克将[1] 黄峻[1] 

机构地区：[1]南京医科大学第一附属医院心内科,江苏南京210029

出　　处：《中华高血压杂志》2010年第4期353-356,共4页Chinese Journal of Hypertension

基　　金：江苏省科技厅国际合作计划(BZ2007077)"江苏自然人群高血压发病早期危险因素研究"资助

摘　　要：目的探讨尿钠排泄量与大小动脉弹性指数(C1,C2)的关系。方法入选体检人群397例(男性195例,女性202例),年龄(53.4±15.1)岁。通过24 h尿钠排泄量测定钠盐摄入量,将入选人群分为低盐组(n=99),低中盐组(n=100),中高盐组(n=99),高盐组(n=99)。C1、C2采用CVProfilor Do-2020动脉脉搏波分析仪测量。使用广义线性模型比较24 h尿钠排泄量与C1、C2的关系,使用多元线性回归分析影响C1、C2的主要因素。结果随着24 h尿钠排泄量的增多,C1、C2逐步降低,其中高盐组较低盐组C1、C2显著降低。多元逐步线性回归分析结果提示24 h尿钠排泄量增高是C1、C2降低的独立危险因素。结论随着24 h尿钠排泄量的增加,反映动脉弹性的指标C1、C2下降。Objective To investigate the relationship between urinary sodium excretion and large arterial compliance（C1） and small arterial compliance（C2）.Methods We enrolled 397 subjects [mean age（53.4±15.1）years,including 195 men and 202 women].These subjects were divided into 4 groups according to their 24-hour urinary sodium excretion,which reflected dietary sodium intake.C1 and C2 were measured by pulse wave analysis（CVProfilor Do-2020）.Statistical methods included general linear model and stepwise regression analysis.Results With increased 24-hour urinary sodium excretion,C1 and C2 decreased.Compared with low sodium intake group,high sodium intake group had a significant lower C1 and C2.Stepwise regression analysis revealed that 24-hour urinary sodium excretion was independently associated with C1 and C2.Conclusion C1 and C2 decreased with increased 24-hour urinary sodium excretion.

关 键 词：大动脉弹性指数 小动脉弹性指数 钠盐 

分 类 号：R544.1[医药卫生—心血管疾病]