VEGF-C在直肠癌中的表达与临床病理特征的关系  

Expression of YEGF-C and it＇s relationship with clinical pathologic characteristics in rectal cancer

作　　者：刘涛[1] 张超[1] 吕伟[1] 甘露[1] 刘立业[1] 陈华[1] 郝迎学[1] 

机构地区：[1]第三军医大学西南医院普外科,重庆400038

出　　处：《中华普通外科杂志》2010年第4期306-308,共3页Chinese Journal of General Surgery

基　　金：全军“十一五”课题资助项目（06MB243）;第三军医大学第一附属医院l临床研究专项基金资助重大项目（2005A001）

摘　　要：目的研究VEGF—C在直肠癌中的表达情况及其与临床病理特征之间的关系。方法对2007年12月至2008年8月行直肠癌手术治疗的82例中低位直肠癌患者的肿瘤组织标本和各站淋巴结，用免疫组化方法检测VEGF—C在直肠癌组织中以及CK20在直肠癌D3站淋巴结中表达的情况，结合系膜淋巴结的病理结果，阐述VEGF—C在直肠癌组织中的表达与临床病理特征之间的关系。统计方法采用χ2检验。结果直肠癌中VEGF—C的表达在肿瘤分期各组中差异有统计学意义（χ2=8．529，P〈0．05），在无淋巴结转移组和系膜淋巴结转移组中差异有统计学意义（χ2=4．712，P〈0．05），在患者性别与年龄对比中差异无统计学意义（χ2=0．227，P〉0．05；χ2=0．037，P〉0．05），无淋巴结转移组与系膜淋巴结转移组的VEGF—C表达差异有统计学意义（χ2=4．712，P〈0．05），而系膜淋巴结转移组与D3淋巴结转移组的表达差异无统计学意义（χ2=0．017，P〉0．05）。结论VEGF—C的表达与肿瘤分期及淋巴结转移有关，但与患者的性别和年龄无关；VEGF—C的表达在促进直肠癌发生区域淋巴结转移的同时，也可能促进D3淋巴结微转移。Objective To study the expression of VEGF-C and it＇s relationship with pathologic characteristics in rectal cancer. Method In this study 82 patients of mid to low rectal cancer underwent radical resection from December 2007 to August 2008. Tumor tissues and lymph nodes were studied by immunohistochemical staining for VEGF-C expression in the tumor tissue and CK20 expression in D3 lymph nodes. Results were compared with the pathological results of mesenterium lymph nodes to explain the relationships between VEGF-C expressions and clinical pathologic characteristics. Data were analyzed with Chi square test. Result As for the expression of VEGF-C, significant differences were found between tumor stages （ χ2= 8. 529, P 〈 0. 05 ） and between positive and negative lymph node metastasis （χ2 = 4. 712, P 〈 0. 05 ） , but there was no difference between that of mesenterium lymph node metastasis and D3 lymph node micrometastasis （χ2 = 0. 017, P 〉 0.05）. Conclusion In rectal cancer, VEGF-C expression is correlated with tumor stage, type, metastasis and micrometastasis of lymph node.

关 键 词：直肠肿瘤 病理学 淋巴结 VEGF-C CK20 微转移 

分 类 号：R735.37[医药卫生—肿瘤]