5,6-二氨基-1-甲基-2,4-(1H,3H)嘧啶二酮的合成  

Synthesis of 5,6-Diamino-1-methyl-2,4(1H,3H)-pyrimidine Dione

作　　者：马玉梅[1] 贾云宏[1] 蔡东[1] 

机构地区：[1]辽宁医学院药学院与研究生学院,辽宁锦州121000

出　　处：《精细化工中间体》2010年第2期51-53,共3页Fine Chemical Intermediates

摘　　要：甲基脲和氰乙酸乙酯在乙醇钠中缩合环化得到6-氨基尿嘧啶钠盐,钠盐酸化得6-氨基-1-甲基-2,4-(1H,3H)嘧啶二酮,再与亚硝酸盐亲电加成得到5-亚硝基-6-氨基-1-甲基-2,4-(1H,3H)嘧啶二酮,最后经连二亚硫酸钠还原得到5,6-二氨基-1-甲基-2,4-(1H,3H)嘧啶二酮,总收率为91.6%,其结构经1HNMR和IR表征。Methylurea and ethyl eyanoaeetate were reacted under catalysis of ethanol sodium to give sodium 6- amino uracil, followed by acidification to form 6--amino-1-methyl-2,4 -（1H, 3H） pyrimidine dione. The later was further converted to 5,6-diamino-1-methyl-2,4（1H, 3H）-pyrimidinedione in two steps. The process afforeded the title compound in 91.6% overall yield, which was confirmed with 1H NMR, IR and elemental analysis.

关 键 词：中间体 6-氨基-1-甲基-2 4-(1H 3H)-嘧啶二酮 5 6-二氨基-1-甲基-2 4-(1H 3H)嘧啶二酮 合成 

分 类 号：TQ254.1[化学工程—有机化工]