重组人表皮生长因子凝胶治疗复发性口腔溃疡临床疗效研究  

Clinical study on recombinant human epidermal growth factor gel in the treatment of patients with recurrent oral ulceration

作　　者：宋丛笑[1] 陈红岩[2] 张严 孙晓菊[1] 

机构地区：[1]辽宁省人民医院口腔科,沈阳110015 [2]大连医科大学,辽宁大连116011 [3]沈阳市和平区张严口腔诊所,沈阳110001

出　　处：《中国实用口腔科杂志》2010年第4期236-237,共2页Chinese Journal of Practical Stomatology

摘　　要：目的探讨重组人表皮生长因子(rhEGF)凝胶治疗复发性口腔溃疡的临床疗效。方法采用随机平行对照试验方法,将2007-2009年辽宁省人民医院口腔科收治64例复发性口腔溃疡(ROU)患者随机分为试验组和对照组,试验组用rhEGF凝胶局部涂药,对照组给予2%碘甘油局部涂药,分组观察,2组均治疗至溃疡愈合或2周止。结果试验组患者溃疡平均愈合时间为(3.52±1.29)d,对照组为(7.58±2.07)d,两组比较,差异有统计学意义(P<0.05)。试验组总有效率(96.9%)明显高于对照组(62.5%)(P<0.05)。结论重组人表皮生长因子凝胶对口腔溃疡创面具有明显的促进愈合作用,应用方便、安全。Objective To investigate the effect of recombinant human epidermal growth factor（rhEGF） gel in treating recurrent oral ulceration. Methods A randomized controlled trial was adopted. Totally 64 patients were divided into two groups：test group （n=32）and control group（n=32）. The test group was given rhEGF gel and control group was given iodine glycerin until the restoration of oral ulcer or for 2 weeks. Results The average curing time of the treatment group was 3.52±1.29 days,but that of the control group was 7.58±2.07 days.The excellent rate of the treatment group（96.9%） was significantly higher than that of the control group（62.5%）（P 0.01）.Conclusion RhEGF gel can promote the restoration of oral ulcer with much convenience and safety.

关 键 词：重组人表皮生长因子 复发性口腔溃疡 碘甘油 

分 类 号：R78[医药卫生—口腔医学]