GSTM家族基因多态性与乳腺癌遗传易感性  

GSTM gene polymorphisms and breast cancer genetic susceptibility

作　　者：陈翱翔[1] 余科达[1] 邵志敏[1] 

机构地区：[1]复旦大学附属肿瘤医院乳腺外科,上海200032

出　　处：《世界临床药物》2010年第5期306-311,共6页World Clinical Drug

基　　金：国家重点基础研究发展计划(973)项目"多基因遗传性肿瘤发病过程中转录组信息和表达规律研究"(2006CB910501);国家自然科学基金"中国遗传性乳腺癌易感基因的定位和临床应用"(30572109)

摘　　要：乳腺癌是复杂性多基因疾病。低外显率基因谷胱甘肽-S-转移酶(GST)基因在乳腺癌遗传易感性中的作用逐渐受到重视。GST基因家族成员之一的GSTM基因的多态性与某些癌症的发生相关联,尽管GSTM基因多态性与乳腺癌遗传易感性的研究尚未获得一致的结论,但相关研究及其进展值得关注。Genetic factors account for a large proportion of breast cancer cases, but a great part of these cases could only be explained by the low-penetrance genes such as GST gene. As a member of the GST gene family, GSTM gene polymorphism correlates with the susceptibility to some cancers. Many investigations have performed the relationship between GSTM polymorphism and the genetic susceptibility to breast cancer. However, the outcomes are inconsistent. This review aims to provide a panorama of the previous researches and to highlight the advances in this field.

关 键 词：乳腺癌 基因 多态性 

分 类 号：R737.9[医药卫生—肿瘤]