部分脾动脉栓塞术治疗脾功能亢进对免疫功能的影响  

Partial Splenic Embolization for Hypersplenism on the Immune Function

作　　者：杨静[1] 胡大为[2] 史丽民[2] 孙建华 

机构地区：[1]承德医学院,河北承德067000 [2]承德医学院附属医院,河北承德067000 [3]河北省滦平县世济医院,河北滦平068250

出　　处：《河北医学》2010年第4期402-405,共4页Hebei Medicine

摘　　要：目的:探讨部分性脾栓塞术(Partial splenic embolization,PSE)治疗脾功能亢进对患者免疫功能的影响。方法:选取确诊为肝癌合并脾亢患者36例,对其施行PSE治疗,观察术前及术后外周血细胞计数(RBC、WBC、PLT)细胞免疫指标(CD3、CD4、CD8、CD4/CD8)以及体液免疫指标(IgM、IgG、IgA)的变化情况。结果:血细胞计数:术后WBC、PLT明显升高,与术前比较有显著性差异(P<0.05),RBC术后与术前比较无明显差异(P>0.05)。②细胞免疫指标:术后CD3细胞比例与术前比较,无显著差异(P>0.05)。术后CD4、CD8、CD4/CD8与术前比较有显著性差异(P<0.05)。③体液免疫指标:术后IgG、IgM与术前比较均无显著性差异(P>0.05),术后28d IgA与术前比较明显上升,有显著性差异(P<0.05)。结论:对肝癌合并脾亢患者实施PSE治疗,不仅血细胞数值有不同程度升高,达到了治疗脾亢的目的,而且保留了部分脾组织来维持机体的免疫平衡,从而使脾亢患者免疫功能得到一定改善,有利于肝癌患者进一步治疗。Objective：To investigate the partial splenic embolization（Partial splenic embolization,PSE）for the treatment of hypersplenism in patients with immune function.Method：Diagnosed with hepatocellular carcinoma with 36 cases of patients with hypersplenism,its implementation of PSE treatment were observed pre-and postoperative peripheral blood count（RBC,WBC,PLT）indicators of cell-mediated immunity（CD3,CD4,CD8,CD4 /CD8）,as well as humoral immunity（IgM,IgG,IgA）was observed.Result：①Cytometry：After WBC,PLT significantly increased compared with the preoperative significant difference（P〈0.05）,RBC postoperative and preoperative was no significant difference（P〉0.05）.②Cell-mediated immunity indicators：After CD3 cell ratio compared with the preoperative data,no significant difference（P〉0.05）.After CD4,CD8,CD4/CD8 and preoperative There were significant differences（P〈0.05）.③Humoral immunity indicators：postoperative IgG,IgM compared with the preoperative was no significant difference（P〉0.05）,after 28 days of IgA significant increase compared with the preoperative data,there is a significant difference（P〈0.05）.Conclusion：Hypersplenism in patients with hepatocellular carcinoma with the implementation of PSE treatment,not only the blood cell values increased to varying degrees,to achieve the purpose of treating hypersplenism,but also to retain some of the spleen to maintain the body＇s immune balance so that immune function in patients with hypersplenism been a definite improvement is conducive to patients with hepatocellular carcinoma for further treatment.

关 键 词：脾栓塞 肝癌 脾功能亢进 免疫功能 

分 类 号：R735.7[医药卫生—肿瘤]