COX-1在宫颈恶性肿瘤组织中的表达及其意义  

Expression of cyclooxygenase-1 in cervical carcinoma and its significance

作　　者：吴琼[1] 赵爱华[1] 王若永[2] 卞丽红[3] 李亚里[1] 

机构地区：[1]解放军总医院妇产科,北京100853 [2]军事医学科学院输血医学研究所,北京100850 [3]解放军307医院妇产科,北京100071

出　　处：《解放军医学杂志》2010年第5期573-575,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：目的探讨环氧化酶-1(COX-1)在宫颈恶性肿瘤组织中的表达及其临床意义。方法收集1999年1月-2005年3月在解放军307医院行手术或活检的62例患者的组织标本,包括31例宫颈癌、15例宫颈上皮内瘤变、16例正常宫颈组织,应用免疫组化SP法检测3种组织中COX-1蛋白的表达差异,并分析COX-1蛋白与患者临床病理特征间的相关性。结果COX-1蛋白主要在细胞质中表达,其次在细胞膜上表达。COX-1蛋白在宫颈癌中呈强阳性表达,在宫颈上皮内瘤变中呈弱阳性表达,表达率分别为81%和13%,差异有统计学意义(P<0.01),而在正常宫颈组织中未见明显阳性表达。COX-1的表达与肿瘤分化程度、临床分期及患者年龄无明显相关性(P>0.05)。结论COX-1蛋白表达可作为宫颈癌的诊断、治疗选择及判断预后的辅助指标。Objective To explore the expression of cyclooxygenase-1 （COX-1） in cervical carcinoma and its significance. Methods The pathological specimens were collected from 62 female patients, who were admitted to 307 Hospital of PLA from Jan. 1999 to Mar. 2005, including 31 cases of cervical carcinomas, 15 cases of cervical intraepithelial neoplasia and 16 cases of normal cervix. Surgery or biopsy was performed. Expression of COX-1 was detected by immunohistochemistry, and the relationship between COX-1 and clinicopathological feature was analyzed. Results The major sites of COX-1 expression were localized in cytoplasm, and next in cell membrane. Strongly positive expression of COX-1 was observed in cervical carcinomas, and weakly positive expression of COX-1 in cervical intra-epithelial neoplasia, with positive rates of 81% and 13%, respectively. There was no COX-1 expression in normal cervix. A significant difference was observed among these specimens. No obvious correlation was found between COX-1 expression and patient＇s age, tumor differentiation degree snd clinical stages. Conclusion Expression of COX-1 may serve as an auxiliary parameter for diagnosis, therapeutic scheme option, and prognosis of patients with cervical carcinoma.

关 键 词：环氧化酶1 宫颈肿瘤 宫颈上皮内瘤样病变 

分 类 号：R737.33[医药卫生—肿瘤]