左心室舒张功能评价方法的研究  

Research on a Novel Method for the Evaluation of Left Ventricular Diastolic Function

作　　者：欧颖[1,2] 张小兵[1] 郑鸣之[2] 包家立[2] 陈莹莹[2] 沈岳 

机构地区：[1]浙江大学基础医学国家理科人才培养基地,杭州310058 [2]浙江大学医学院生理教研室,杭州310058

出　　处：《生物医学工程学杂志》2010年第2期270-273,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30470635);国家基础科学人才培养基金能力提高项目资助(J0730856/J0108);条件建设项目资助(J0830833/J0108)

摘　　要：目前国内缺乏能够全面而简单地评价左心室舒张功能的方法。为了解决这个问题,我们根据一定的数学模型,建立了算法,从而提出一种新方法,通过采用MATLAB语言编写的程序来实现。这种方法主要是根据左心室内压P的变化,得到P-dP/dT环,并计算出左心室舒张末压(LVEDP)、最大左心室舒张速率(-(dP/dt)max)、等容舒张期时间常数(τ)和室腔僵硬度常数(Kd)这四个重要指标。从离体心脏缺血/再灌注实验得到的结果证明了这种方法的可行性和有效性。因此这种使用τ和Kd指标的方法对评价左心室舒张功能是敏感而有效的,可以应用于左心室舒张功能异常的早期检测。The methods for evaluating left ventricular diastolic function completely and simply are lacking in our country at present.To solve this problem,we presents in this paper a novel method,which is developed according to certain algorithms and mathematic models and is carried out by a MATLAB program.This method mainly obtains dP/dt loops,and calculates four important indices,including left ventricular end-diastolic pressure（LVEDP）,Maximal decrease in velocity of left ventricular pressure（-（dP/dt）max）,Time constant of ventricular isovolumic relaxation（τ） and Chamber stiffness（Kd）,according to the changes of left ventricular pressure.The results obtained from the experiment of isolated rat hearts during ischemia/reperfusion have demonstrated the usefulness and validity of this method.Therefore,with the use of τ and Kd as indicators,this is a sensitive and effective method for evaluating the left ventricular diastolic function,and it can be applied to early detection of left ventricular diastolic dysfunction.

关 键 词：MATLAB 左心室舒张功能 等容舒张期时间常数 室腔僵硬度常数 

分 类 号：R541[医药卫生—心血管疾病]