谷氨酸受体及其在弱视方面研究进展  

Advances in glutamate receptor and it's relationship with amblyopia

作　　者：王宗青[1] 刘向玲[1] 穆雅林 

机构地区：[1]中国河南省三门峡市黄河医院眼科,472000

出　　处：《国际眼科杂志》2010年第5期915-917,共3页International Eye Science

摘　　要：谷氨酸受体可分为促离子型谷氨酸受体(iGluR)和促代谢型谷氨酸受体(mGluR),促离子型受体可分为NMDA型受体和非NMDA型受体。促代谢型受体包括mGluR1～mGluR88种。其在中枢神经系统分布广泛,与突触的可塑性、谷氨酸的兴奋毒性、神经元的损伤与保护、长时程增强(LTP)和长时程抑制(LTD)、学习和记忆等多种功能密切相关。在弱视方面研究较多的是NMDA受体,其数量、活性在弱视组与正常组相比都有显著性差异。Glutamate receptor can be divided into metabotropic receptor（mGluR） and ionotropic receptor（iGluR）. The iGluR includes NMDA receptor and non-NMDA receptor. mGluR includes mGluR1 to mGluR8. They are mainly distributed in the central nervous system （CNS） . They have an important role in synaptic plasticity, exitotoxicity of glutamate, protection and damage of neuron, long-term potentiation（LTP） and long-term depression（LTD）, study and memory. The NMDA receptor is studied considerably in amblyopia. There are significant differences in quantity and activity between contrast group and amblyopia group.

关 键 词：谷氨酸受体 突触可塑性 弱视 兴奋毒性 

分 类 号：R777.44[医药卫生—眼科]