光动力联合TA后Tenon囊下注射治疗多灶性脉络膜炎合并CNV疗效观察  

Therapeutic effect of photodynamic therapy and injection of triamcinolone acetonide via posterior sub-tenon combination therapy on choroidal neovascularization combined with multifocal choroiditis

作　　者：殷海泉[1] 徐丽[2] 殷亮[3] 

机构地区：[1]中国辽宁省阜新市中心医院眼科,123000 [2]中国辽宁省沈阳市第四人民医院眼科,110031 [3]中国天津市第四中心医院眼科,300000

出　　处：《国际眼科杂志》2010年第5期968-970,共3页International Eye Science

摘　　要：目的:评价光动力疗法(photodynamic therapy,PDT)联合曲安奈德(triamcinolone acetonide,TA)后Tenon囊下注射,治疗多灶性脉络膜炎(multifocal choroiditis,MC)合并脉络膜新生血管(choroidal neovascularization,CNV)的临床疗效。方法:回顾性分析8例8眼临床确诊为MC合并CNV患者的临床资料,对比分析PDT联合TA后Tenon囊下注射治疗前后患者最佳矫正视力(BCVA),FFA/ICGA和OCT等检查结果的变化。结果:联合治疗后随访6mo,所有患者BCVA与治疗前相比均明显提高,差异具有统计学意义(P<0.05)。FFA/ICGA检查显示,联合治疗后1moMC前节及眼底活动性炎症减退或停止者8眼(100%),CNV病灶渗漏停止或渗漏减少者7眼(88%)持续渗漏1眼(12%)。PDT治疗后6mo,MC炎症未发现复发,CNV病灶渗漏停止或渗漏减少者8眼(100%)。OCT显示CNV缩小,组织水肿减轻。结论:PDT联合TA后Tenon囊下注射治疗多灶性脉络膜炎合并脉络膜新生血管安全有效。AIM：To investigate the efficacy of photodynamic therapy （PDT） and injection of triamcinolone acetonide （TA） via posterior sub-tenon combination therapy on choroidal neovascularization （CNV） combined with multifocal choroiditis （MC）. METHODS： Eight patients （8 eyes） who were diagnosed as MC combined with CNV were retrospectively analyzed. The changes in the best-corrected visual acuity（BCVA）, FFA/ICGA and OCT were analyzed before and after combination therapy. RESULTS： During 6-month follow-up the BCVA was improved after combination therapy （P〈0.05）. FFA/ICGA showed decrease and stoppage of inflammation on preocular and fundus in 8 eyes（100%）,no leakage or reduced leakage in 7 eyes（88%） 1 month after combina-tion therapy. In 1 eye （12%）, the fundus remained leaky. At the 6-month follow-up, no inflammation relapse was obtained,FFA / ICGA showed no leakage or slight leakage in 8 eyes （100%）. CONCLUSION：Combination therapy of PDT and injec-tion of TA via posterior sub-tenon is safe and effective to CNV combined with MC. 

关 键 词：光动力疗法 曲安奈德 后Tenon囊 多灶性脉络膜炎 脉络膜新生血管 

分 类 号：R773[医药卫生—眼科]