槲皮素类似物关键中间体的合成研究  

Study on the synthesis of intermediate of quercetin analogues

作　　者：陈丹[1] 李鹰[2] 王淑燕[1] 徐克磊[1] 郑永胜[1] 郭举[1] 田之悦[3] 成丽[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]四川大学生命科学学院,四川成都610064 [3]四川大学化学学院,四川成都610065

出　　处：《化学研究与应用》2010年第5期592-595,共4页Chemical Research and Application

基　　金：四川省科技厅资助项目(2009JY0034)

摘　　要：A series of key intermediates of quercetin analogues were designed and synthesized in this paper.Acetophenone derivatives were got by using phloroglucinol as raw material through the Hoesch reaction and dimethyl sulphate to protect its 4,6-dihydroxyl,from which three key intermediates were synthesized through two different pathways:5,7-dimethoxy-2-cyano-benzopyran-4-one(6),5,7-dimethoxy-benzopyran-4-one(8),5,7-dimethoxy-2,3-epoxy-benzopyran-4-one(9).All the compounds were confirmed by MS and 1H-NMR.A series of key intermediates of quercetin analogues were designed and synthesized in this paper.Acetophenone derivatives were got by using phloroglucinol as raw material through the Hoesch reaction and dimethyl sulphate to protect its 4,6-dihydroxyl,from which three key intermediates were synthesized through two different pathways：5,7-dimethoxy-2-cyano-benzopyran-4-one（6）,5,7-dimethoxy-benzopyran-4-one（8）,5,7-dimethoxy-2,3-epoxy-benzopyran-4-one（9）.All the compounds were confirmed by MS and 1H-NMR.

关 键 词：间苯三酚 槲皮素类似物 中间体 合成 

分 类 号：O621.3[理学—有机化学]