PETA-3/CD151在乳腺癌组织芯片中的表达及意义  

Expressions of CD151 in breast cancer tissue microarray and its significance

作　　者：刘婷[1] 张春庆[1] 柏青杨[1] 李小青[2] 兴桂华[1] 

机构地区：[1]齐齐哈尔医学院 [2]天津医科大学肿瘤研究所

出　　处：《齐齐哈尔医学院学报》2010年第5期677-679,共3页Journal of Qiqihar Medical University

基　　金：黑龙江省教育厅资金资助课题(编号:11511453)

摘　　要：目的研究穿膜蛋白CD151在乳腺癌中的蛋白表达及与乳腺癌发生发展、转移和预后的关系。方法构建乳腺癌组织芯片,采用免疫组化SP法检测CD151的蛋白表达,探讨与临床病理资料之间的关系。定性资料间的比较,采用χ2检验。P<0.05为差异有统计学意义。结果 CD151在正常乳腺组织中的阳性表达率为0.0%(0/39);在原位癌组织和浸润性乳腺癌组织中阳性表达率分别为33.3%(10/30)和59.0%(59/100),三组间比较差异有统计学意义(χ2=41.276,P=0.000)。CD151蛋白表达与乳腺癌患者的年龄和组织学类型无关(P>0.05);但与肿瘤大小、ER/PR表达、淋巴结转移、肿瘤分化程度、TNM分期有密切关系(P<0.05)。结论 CD151在乳腺癌组织中存在异常高表达并与乳腺癌发生发展、浸润转移有密切关系。检测可作为判断乳腺癌生物学行为和预后的重要指标,尤其对ER(-)/PR(-)乳癌的判断更具有价值。Objective To evaluate the expression of CD151 in human breast cancer and its relations with the occurrence and development and metastasis and prognosis of breast cancer. Methods By using immunohistochemical S-P method,the expression of CD151 protein in breast cancer tissue microarray（TMA） was tested.The correlations with clinicopathological features were analyzed.Comparison between qualitative data was performed by Chi-square test.The difference was considered significant（P〈0.05）.Results The positive rate of CD151 expressions was 0.0%（0/39）in normal breast tissue,33.3%（10/30）in tissues of carcinoma in situ and 59.0%（59/100） in cancerous tissues respectively.The difference of the protein expression rate among the three groups was significant（χ^2=41.276,P=0.000）.The CD151 expression in invasive breast cancer tissues wasn＇t associated with patient＇s ages,and the histological type（P〉0.05）.But it was significantly related with tumor size and ER/PR expression,differentiated degree of cancer tissue,lymph node metastasis and TNM（P〈0.05）.Conclusions The expression of CD151 was over expressed in breast carcinoma,which suggested that the protein was related to carcinogenesis,development,invasion and metastasis.Detection the maker can be used to determine the biological behavior and prognosis of breast cancer.In particular,it would be more valuable on the breast cancer with ER（-）/PR（-）.

关 键 词：CD151 乳腺癌 组织芯片 

分 类 号：R739.85[医药卫生—肿瘤]