结肠癌患者血清细胞质胸苷激酶的检测及临床意义  

The clinical significance of serum cytosolic thymidine kinase determination in patients with colon cancer

作　　者：方辉[1] 李学良[2] 施瑞华[2] 

机构地区：[1]江苏省人民医院·南通瑞慈医院消化科,226010 [2]江苏省人民医院消化科

出　　处：《中国医师进修杂志》2010年第13期30-32,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨血清细胞质胸苷激酶（TK1）的检测在结肠癌诊治中的临床价值.方法 利用增强化学发光法检测80例结肠癌患者（结肠癌组）血清TK1的含量,同时检测98例结肠息肉（结肠息肉组）和90例健康体检者（对照组）血清中的TK1含量.结果 结肠癌组TK1水平[2.87（1.51～4.36）pmol/L]显著高于结肠息肉组[1.25（0.85～1.52）pmol/L]和对照组[1.17（0.68～1.42）pmol/L]（P〈0.05）;而结肠息肉组和对照组之间差异无统计学意义（P〉0.05）.62例结肠癌患者行扩大根治术后血清TK1水平较术前明显下降（P〈0.05）.结肠癌组血清TK1检测阳性率61.25%（49/80）,与癌胚抗原（CEA）检测阳性率（58.75%,47/80）比较差异无统计学意义（P〉0.05）.TK1与CEA联合检测,检测阳性率可提高到68.75%（55/80）.结论 血清TK1检测在结肠癌早期诊断、疗效监测、预后判断等方面具有一定的临床应用价值.Objective To investigate the diagnostic value of serum cytosolic thymidine kinase（TK1）in patients with colon cancer.Method The Ievels df TK1 in 80 patients with colon cancer,98patients with colon polyps and 90 normal controls were determined by enhanced chemiluminescence assay（ECLA）.Results The levels of TK1 in patients with colon cancer[2.87（1.51～4.36）pmol/L]were much higher than those in patients with colon polyps[1.25（0.85-1.52）pmol/L]and normal controls[1.17（0.68-1.42）pmol/L]（P〈0.05）,but there was no significant difference between patients of colon polyps and normal controls（P〉0.05）.The levels of TK1 declined significantly after operation in patients with colon cancer（P〈0.05）.There was no significant difference in the positive rate between TK1 and carcinoembryonic antigen（CEA）in patients with colon cancer[61.25%（49/80）vs 58.75%（47/80）,P〉0.05].The detection of TK1 combined with CEA could increase the positive rate to 68.75%（55/80）.Conclusion The detection of TK1 may have value in the early diagnosis,monitoring and prognosis of colon cancer.

关 键 词：胸苷激酶 癌胚抗原 结肠肿瘤 增强化学发光法 

分 类 号：R735[医药卫生—肿瘤]