蛋白酪氨酸磷酸酶-PEST在生理调节及相关疾病中的作用  

Role of protein tyrosine phosphatase-PEST in physiological regulation and diseases

作　　者：李妮娅[1] 李登清[1] 董辉 

机构地区：[1]中南大学湘雅医学院检验系,长沙410013 [2]国家人类基因组南方研究中心,上海201203

出　　处：《生命的化学》2010年第2期241-245,共5页Chemistry of Life

摘　　要：蛋白质分子中酪氨酸残基可逆性的磷酸化是细胞内信号分子传导的基本方式。两类作用相反的酶参与磷酸化的调节:蛋白酪氨酸激酶(protein tyrosinekinase,PTK)和蛋白酪氨酸磷酸酶(protein tyrosine phosphatase,PTP)。含脯氨酸-谷氨酸-丝氨酸-苏氨酸(P-E-S-T)结构域的蛋白酪氨酸磷酸酶(PTP-PEST)属于非受体型酪氨酸磷酸酶类,其本身能与多种蛋白质相互作用,并在细胞迁移、免疫细胞活化和胚胎发育等生理过程中发挥重要作用。本文对PTP-PEST的结构特点、生理功效、介导的信号传导途径和近年来PTP-PEST在疾病中的作用作一综述。The reversible phosphorylation of tyrosine residues in protein is an important mechanism involved in cellular signal transduction.It is well known that two different enzymes participate in the regulation of phosphorylation： protein tyrosine kinases （PTK） and protein tyrosine phosphatase （PTP）.PTP-PEST belongs to the non-receptor protein tyrosine phosphatases which play important roles in cell migration,activation of immunocytes and embryonic development through interacting with a lot of proteins.In this review,we will focus on the recent studies on the structure of PTP-PEST,its physiological function,the signal transduction pathways and diseases it is supposed to be involved in.

关 键 词：蛋白酪氨酸磷酸酶 PTP-PEST 去磷酸化 信号传导 

分 类 号：R362[医药卫生—病理学]