染料木黄酮的雌激素活性对辐照小鼠免疫功能的影响  

EFFECTS OF THE ESTROGENIC ACTIVITIES OF GENISTEIN ON IMMUNE RESPONSE IN IRRADIATED MICE

作　　者：薛春洪[1] 金宏[1] 李培兵[1] 王永辉[1] 南文考[1] 邓炳楠[1] 

机构地区：[1]卫生学环境医学研究所,天津300050

出　　处：《营养学报》2010年第2期170-173,共4页Acta Nutrimenta Sinica

摘　　要：目的研究染料木黄酮(genistein,Gen)的雌激素效应对辐射损伤的防护作用,为抗辐射功能食品的开发和对原有辐射防护剂的改进提供实验依据。方法观察应用他莫西芬(ERα阻断剂)和Faslodex(ERβ阻断剂)阻断受照小鼠雌激素受体(ER)活化情况下,Gen对接受4Gy全身照射小鼠血白细胞和淋巴细胞计数、血清溶血素及迟发型变态反应的影响。结果Gen可以降低辐照小鼠的血白细胞和淋巴细胞的减少幅度,增强免疫功能;他莫西芬与Gen合用对小鼠血白细胞和淋巴细胞计数及免疫功能无明显影响,表明他莫西芬不能阻断Gen对辐照的保护作用。Faslodex与Gen合用则仍降低受照小鼠血白细胞和淋巴细胞数量,也抑制免疫功能。表明Faslodex能阻断Gen的保护作用。结论Gen通过激活ERβ途径,增强辐射小鼠的免疫功能。Objective To study the radiation-protective effects produced by the estrogenic activities of genistein（Gen） for providing experimental basis to develop the food for radiation protection. Method After blocking estrogen receptor （ER） activities by Tamoxifen and Faslodex,the effects of Gen on peripheral leucocytes and lymphocyte counts,serum haemolysin and delayed type of hypersensitivity of the mice were examined after exposure to 4 Gy γ radiation. Results Gen was shown to inhibit the decrease of peripheral leucocytes and lymphocyte counts and the decreased immune response of the γ-irradiated mice. Faslodex （ERβ blocker） ＋ Gen eliminated the protective effect of Gen and still caused the similar effects in hematological response and immune response after irradiation. Tamoxifen （ERα blocker） did not have these effects. Conclusion Gen can enhance the immune function in irradiated mice through activation of estrogen receptor β pathway.

关 键 词：染料木黄酮 辐射 免疫 

分 类 号：R151[医药卫生—营养与食品卫生学]