凋亡抑制蛋白survivin在胃癌组织中的表达及意义  

Survivin expression in gastric carcinoma and its prognostic significance

作　　者：苏晋捷[1] 曾祥福[1] 刘晓平[1] 冯起放[1] 

机构地区：[1]赣南医学院第一附属医院普外二科,江西省赣州市341000

出　　处：《实用医学杂志》2010年第8期1345-1347,共3页The Journal of Practical Medicine

基　　金：江西省卫生厅课题资助项目(编号:20063168)

摘　　要：目的:研究凋亡抑制蛋白survivin在胃癌组织中的表达情况,探讨该基因对胃癌复发、远处转移及预后的意义。方法:将胃癌组织中survivin的表达用免疫组化法进行检测,按survivin是否表达分为表达阳性与阴性两组,同时行相同的治疗(化疗与抗肿瘤)。对两组病例进行随访,比较两组患者的预后情况。结果:共有78例患者纳入研究和随访观察,47例患者标本survivin呈现不同程度的阳性表达,阳性率60.25%。survivin阳性组术后12～24个月复发率(51±2)%高于survivin阴性组(9±1)%,两者差异有显著性(P<0.05)。结论:随着胃癌浸润程度的加深,survivin的阳性表达率升高;survivin基因表达阳性患者术后复发转移较对照组早。Survivin蛋白可以作为胃癌预后判断的标志物之一。Objective To investigate the role of survivin in predicting recurrence, distant metastasis, and prognosis of gastric carcinoma by understanding the expression of survivin. Methods Survivin expression in gastric carcinoma was detected by immunohistochemical assay. The patients were divided into two groups （survivin positive and survivin negative groups） according to the status of survivin expression. They all received identical chemotherapy and other treatment and were followed up. The recurrence, distant metastasis, and prognosis of the disease in the two groups were compared. Results 78 patients were included in this study. 47 of the patients were survivin positive, with a positive rate of 60.25%. 12 to 24 months after treatemt,the recurrence rate was significantly higher in the survivin positive group than in the survivin negative group （[51 ＋ 2]% vs. [9 ＋ 11%, P 〈 0.05）. Conclusions The expression rate of survivin is increased with the rising degree of malignant infiltration. Metastasis and recurrence oceurr earlier in the patients with positive survivin expression after therapy. Sarvivin can be used as one of the markers to predict the prognosis of gastric carcinoma.

关 键 词：胃肿瘤 SURVIVIN 预后 

分 类 号：R735.2[医药卫生—肿瘤]