原发性肝癌超声造影灌注改变与生物学特性关系研究  

Study on the relationship between the contrast enhanced ultrasound and biological characteristics of primary hepatocellular carcinoma

作　　者：杨龙[1] 王绮[1] 吴刚[1] 袁建军[1] 郝远瑞[2] 田建国[3] 

机构地区：[1]河南省人民医院超声科,郑州市450003 [2]河南省人民医院病理科,郑州市450003 [3]河南省人民医院肝胆外科,郑州市450003

出　　处：《中华实用诊断与治疗杂志》2010年第5期450-451,共2页Journal of Chinese Practical Diagnosis and Therapy

基　　金：河南省重点攻关项目(0523030400)

摘　　要：目的:探讨原发性肝细胞性肝癌超声造影表现与其生物学特性的关系。方法:原发性肝细胞性肝癌患者89例113个病灶,选择动脉相灌注特征、超声造影增强后肿瘤大小变化等生物学参数进行观察。全部病例经病理证实并与分级对照,部分病例检测微血管密度。结果:依超声造影改变将原发性肝细胞性肝癌灌注显像分为4型:树枝型、混合型、环绕型、网络型。综合超声造影灌注特征、病理、微血管密度、预后等多个参数,树枝型为浸润性生长,环绕型为膨胀性生长,其余2型介于二者之间为过渡型。结论:超声造影动脉期灌注显像特征及强化后肿瘤大小及轮廓的变化,反映了原发性肝细胞性肝癌生长方式及微血管密度与部位,可作为评估原发性肝细胞性肝癌生物学行为方法。Objective To study the relationship between different performance of contrast enhanced ultrasound and biological characteristics of hepatocellular carcinoma.Methods Eighty-nine patients（113 lesions） with hepatocellular carcinoma were observed the biological parameters as arterial phase perfusion features and the changes of the size of tumor after enhancement.All cases were pathologically confirmed and graded,and some were measured the microvessel density.Results The perfusion imaging of hepatocellular carcinoma was divided into 4 types： branch type,mixed type,ring type and network type.Considering the contrast enhanced ultrasound perfusion characteristics,pathology,microvessel density,and other prognostic parameters,the branch type was of infiltrative growth,the ring type was of expansionary growth,and the other types were of transitional type.Conclusion Arterial phase perfusion imaging features and enhanced tumor size and contour changes during contrast enhanced ultrasound reflect the way of the growth of hepatocellular carcinoma and the microvessel site and density.It can serve as a method to assess the biological behavior of hepatocellular carcinoma.

关 键 词：超声造影 原发性肝细胞性癌 生物学特性 

分 类 号：R735.7[医药卫生—肿瘤]