外周血淋巴细胞β受体变化与哮喘遗传的相关研究  

A relationship on the changes of the circulationg lymphocyte βadrenoceptors and bronchial asthma heredity

作　　者：吴葆菁 麦贤弟 卢汉平[2] 高锦辉[2] 

机构地区：[1]广州孙逸仙纪念医院儿科,510120 [2]中山医科大学核医学教研室

出　　处：《中国优生与遗传杂志》1999年第1期16-16,20,共2页Chinese Journal of Birth Health & Heredity

摘　　要：本文采用放射配基受体结合分析方法，对支气管哮喘急性发作期患儿及其父亲外用血淋巴细胞肾上腺素能β受体（简称β-AR）及血浆cAMP水平进行观察。结果显示哮喘发作期患儿外周血淋巴细胞β-AR为4148．3±372．5site/cellcAMP为17．0±1．5pm／ml，患儿父亲β-AR为2176±678．2site／call，cAMP为14．4±2．0PM／ml，．患儿母亲β-AR为1721．1±96．3site／site,cAMP为13．3±1．4pm／ml，哮喘息性发作期患儿及其父母的外周血淋巴细胞β-AR密度均明显升高P＜0．01，表明哮喘患儿及其父母的β-AR功能低下或受到阻滞。而且患儿与其父母亲之间存在一定的遗传倾向。父母亲β-AR功能低下，其小儿可能易患支气管哮喘，小儿气道上的β-AR由于遗传因素影响而处于反应低下，可能是小儿支气管哮喘高发的基础。The differences changes of β-adrenoceptors in circulating lymphocytes and cAMP in plasma of the acute bronchial asthme children and their parents. Of the asthma children, β-adrenoceptor was 4148. 3 ± 372. 5 site/cell, cAMP 17 ± 1. 5pm/ml; ofthe children's father, β-adrenoceptor was 2176. 6 ± 678. 2 site/cell, cAMP was 14. 4 ± 2. 0pm/ml; of the children's mother, βadrenoceptor was 1721 ± 96. 3 site/cell, cAMP was 13. 30 ± 1.4pm/ml. The β-adrenoceptors of the asthma children and their parents was increased signficantly, P< 0. 01, but cAMP was decreased significantly P< 0. 01. It was suggested that bronchialasthma children and their parents had β-adrenoceptor disfunction and heredity tend. The children whine parents had β-adrenoceptor disfunction may easily cause bronchial asthma.

关 键 词：遗传学 哮喘 淋巴细胞β 外周血 受体 

分 类 号：R562.250.2[医药卫生—呼吸系统]