依达拉奉治疗急性脑出血37例的疗效评价  

The evaluate of therapeutic effects of edaravone in 37 patients with acute cerebra l hemorrhage

作　　者：李雷[1] 于利霞[2] 于婷[3] 

机构地区：[1]济宁医学院,272013 [2]山东省贸易职工大学医院 [3]济宁市第一人民医院

出　　处：《中国实用医药》2010年第14期45-46,共2页China Practical Medicine

摘　　要：目的观察依达拉奉对急性脑出血的临床疗效。方法将66例脑出血患者随机分为治疗组(37例)和对照组(29例),对照组采用常规治疗;治疗组在常规治疗的基础上给予依达拉奉应用共14d。两组均在治疗前及治疗后14d进行神经功能缺损评分、疗效评定及血清神经元特异性烯醇化酶(NSE)浓度测定。结果治疗组在14d后神经功能缺损评分改善明显优于对照组;疗效(有效率91.89%)优于对照组(有效率79.31%);治疗后依达拉奉组血清NSE的浓度较常规治疗组下降更明显(P<0.05)。结论依达拉奉可以减轻急性脑出血的炎症反应,降低神经功能缺损程度。Objective To observe the effect of edaravoneon on the treatment of acute cerebral hemorrhage.Methods 66 cases were divided into treatment group（37 cases） and control group（29 cases） randomly,control group were given conventional therapy,and treatment group were given edaravone and conventional treatment for 14 days.Before and after 14 days,the patients in two groups were recorded on neurological function feficit scores,efficacy assessment and plasma level of neuron-specific enolase （NSE）.Results After 14 days,the improvement of neurological function deficit scores of treatment group was superior to control group.And the efficacy of treatment group （ efficiency：91.89% ） was higher than control group （ efficiency：79.31% ）.The NSE levels of the treatment groups were lower than control group obviously （P0.05）.Conclusion Edaravone can reduce the inflammatory reaction and decrease the degree of neural function damage on acute cerebral hemorrhage.

关 键 词：脑出血 依达拉奉 神经元特异性烯醇化酶 临床疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]