复方苦参注射液在预防化疗所致肝损害方面的研究  

Study of compound matrine injection on preventing hepatic lesion caused by chemotherapy

作　　者：陈晓秋[1] 刘楠楠[1] 申东兰[1] 

机构地区：[1]北京大学深圳医院肿瘤科,518036

出　　处：《肿瘤研究与临床》2010年第4期261-263,共3页Cancer Research and Clinic

摘　　要：目的探讨复方苦参注射液对胃癌及大肠癌术后辅助化疗所致肝损害的预防作用。方法将178例胃癌及大肠癌根治术后患者随机分成3组，A组56例，给予MFOLFOX6方案化疗；B组62例，化疗同时加用复方苦参注射液；c组60例，化疗同时加用还原型谷胱甘肽。观察3组出现肝功能损害的例数、程度和时间。结果各组均未见Ⅲ度及以上肝脏毒性发生；B组、C组胆红素及氨基转移酶升高发生率均低于A组，差异有统计学意义（P〈0．05），而碱性磷酸酶（ALP）／γ一谷氨酰转移酶（GGT）升高发生率，三组比较差异无统计学意义（P〉0．05）；A组肝损害患者72．7％首次发生于第7周期化疗前，而B组和C组分别为273％、33．3％，B组、C组肝损害发生时间均明显迟于A组，差异有统计学意义（P〈0．05）；不论在胆红素和氨基转移酶升高发生率或是肝损害发生时间上，B组与c组比较差异均无统计学意义（P〉0．05）。结论复方苦参注射液可预防并延迟胃肠道恶性肿瘤术后辅助化疗所致肝损害的发生，效果与还原型谷胱甘肽相当，又因其不良反应轻并具备抗肿瘤作用，故更具临床优势。Objective To evaluate the preventive effect of compound matrine injection on hepatic lesion caused by chemotherapy. Methods 178 patients after gastric and coloreetal cancer resection were enrolled into three groups randomly. 56 patients in group A received MFOLFOX6 regimen treatment only, 62 patients in group B received both normal treatment and combined compound matrine injection,60 patients in group C received both normal treatment and glutathione. The change of liver function were observed. Results There was no the hepatotoxicity ofⅢ-Ⅳ degree in all groups;the incidence of bilirubin and transaminase increasing in group B and C was significantly lower than that group A（P 〈0.05）, but the incidence of ALP/GGT increasing showing no significant difference among the ＇three groups; 72.7 % of the incidence of hepatic lesion in group A happened firstly before the seventh cycle,it was 27.3 % and 33.3 % respectively in group B and group C, the time of the emerging of hepatotoxicity in group B and C was markedly delayed than that group A （P 〈0.05）; there was not significant difference between group B and group C in both bilirubin and trausaminase increasing and the time of the emerging of hepatotoxicity （P 〉0.05）. Conclusion Compound matrine injection can prevent and postpone the happening of hepatic lesion caused by adjuvant chemotherapy after digestive tract cancer resection, The result is equal to glutathione. Compound matrine injection also has autineoplastic effects, so the clinical superiority is more obvious.

关 键 词：中药疗法 抗肿瘤联合化疗方案 肝疾病 预防和防护用药 

分 类 号：R735[医药卫生—肿瘤]