超声光散射成像与全数字化乳腺摄影对乳腺肿瘤诊断的对比研究  

Comparative study of ultrasonography-guided optical imaging system and full-field digital mammography in breast neoplasms

作　　者：李嘉[1] 滕皋军[2] 张炽敏[1] 姚小留[1] 赵天慧[1] 刘万花[2] 魏晓莹[3] 陈卫东[4] 王玲[1] 

机构地区：[1]东南大学附属中大医院超声诊断科,南京210009 [2]东南大学附属中大医院放射科,南京210009 [3]东南大学附属中大医院病理科,南京210009 [4]东南大学附属中大医院普外科,南京210009

出　　处：《中华放射学杂志》2010年第5期470-472,共3页Chinese Journal of Radiology

基　　金：江苏省卫生厅课题资助项目（H200756）

摘　　要：目的 比较超声光散射成像（OPTIMUS）与全数字化乳腺摄影（FFDM）对乳腺肿瘤的诊断价值.方法 64例拟诊乳腺肿瘤患者,术前采用双盲方法均行OPTIMUS和FFDM检查,以手术病理结果作为对照,判断肿块的良、恶性质.采用x2检验,将OPTIMUS结果与FFDM结果作对比分析.结果 经OPTIMUS和FFDM检查均检测到65个乳腺肿块.OPTIMUS结果与病理结果比较,诊断正确率为86.2%（56/65）,敏感度为87.0%（20/23）,特异度为85.7%（36/42）,阳性似然比6.09,阴性似然比0.175.FFDM诊断正确率为73.8%（48/65）,敏感度为82.6%（19/23）,特异度为71.4%（30/42）,阳性似然比2.891,阴性似然比0.243.经统计学分析,术前OPTIMUS与FFDM检查对乳腺肿瘤定性诊断差异无统计学意义（x2=3.077,P＞0.05）.结论 OPTIMUS与FFDM诊断水平相当,二者优势互补,能够成为当前乳腺疾病影像诊断技术有效的、必要的补充手段.Objective To compare the diagnostic values of US-guided optical imaging system （OPTIMUS） and full-field digital mammography （FFDM） in breast neoplasms. Methods Sixty-four patients suspected of breast neoplasms underwent OPTIMUS and FFDM before surgery. All patients were proved histopathologically. The accuracy of diagnosis was compared with chi-square test. Results Sixty-five masses were delineated by OPTIMUS and FFDM. The diagnostic accuracy, sensitivity and specificity of OPTIMUS were 86. 2% （ 56/65 ）, 87.0% （ 20/23 ） and 85.7% （ 36/42 ）, respectively. The positive likelihood ratio was 6. 09 and the negative likelihood ratio was 0. 175. The diagnostic accuracy, sensitivity and specificity of FFDM were 73.8% （48/65）, 82. 6% （ 19/23 ） and 71.4% （30/42）, respectively. The positive likelihood ratio was 2. 892 and the negative likelihood ratio was 0. 243. There were no significant differences between OPTIMUS and FFDM （ x2 = 3. 077 ,P 〉 0. 05）. Conclusion OPTIMUS is similar and supplementary to FFDM for the diagnosis of breast neoplasms.

关 键 词：超声检查 乳房 乳腺肿瘤 乳房X线摄影术 

分 类 号：R737.9[医药卫生—肿瘤]