脂质组成对硫辛酸脂质纳米粒的制备及其稳定性的影响  

Effect of Lipid Matrix on the Preparation and Stability of α-Lipoic Acid Loaded Nanostructured Lipid Carriers

作　　者：邹爱华[1] 郑锴[1] 夏强[2,3] 叶汝强[1] 牟伯中[1] 

机构地区：[1]华东理工大学应用化学研究所,上海200237 [2]东南大学生物科学与医学工程学院,南京210096 [3]东南大学苏州市生物医用材料与技术重点实验室,苏州215123

出　　处：《化学通报》2010年第5期431-436,共6页Chemistry

基　　金：科技部国际合作重大项目(2008DFB50060);教育部博士点新教师基金项目(200802511024)资助

摘　　要：采用高压均质法制备硫辛酸(ALA)脂质纳米粒(ALA-NLC),确定了负载ALA的最佳体系。通过高效液相色谱、动态光散射、流变等测试研究了脂质成分、含量对ALA负载、ALA-NLC稳定性和分散液流变性质的影响,并用原子力显微镜观察了ALA-NLC的形貌。结果表明,脂质/ALA质量比在4.5∶1～6∶1之间,得到的脂质纳米粒分散均匀,颗粒规则;脂质中液态油脂的增加有利于保持ALA-NLC的粒径,储存稳定性和分散液的低粘度,并得到两个有望用于食品工业的ALA-NLC配方。Nanostructured lipid carriers of α-lipoic acid（ALA-NLC ） were prepared by high pressure homogenization method.High efficiency liquid chromatography,dynamic light-scattering,rheological measurements were used to determine the lipid matrix effect on the load of ALA,stability of ALA-NLC and rheological property of ALA-NLC dispersions.The morphology of ALA-NLC was observed by AFM.The results showed that the ALA-NLC was the regular nanoparticle when the weight ratio of lipid matrix /ALA ranged between 4.5：1 and 6：1.Moreover,the increase of liquid lipid in the lipid matrix will lead to the improvement of the ALA load,the stability of NLC,and the lower viscosity of ALA-NLC dispersions.Two formulations for dietary supplement of ALA-NLC were obtained.

关 键 词：脂质纳米粒 硫辛酸 脂质 高压均质 

分 类 号：R943[医药卫生—药剂学]