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作 者:胡砚平[1,2] 尤金朝[1,2] 赵炜[1,2] 程筠[1,2] 杨海东[1,2] 陈弈[1,2]
机构地区:[1]厦门市口腔医院 [2]福建医科大学教学医院口腔颌面外科,福建厦门361003
出 处:《口腔医学研究》2010年第2期212-214,共3页Journal of Oral Science Research
基 金:厦门市卫生局资助
摘 要:目的:明确RANKL在牙源性角化囊肿中的表达和分布,了解牙源性角化囊肿骨破坏的机制。方法:经病理诊断的牙源性角化囊肿组织切片,用免疫组化法检测RANKL的表达及分布,用TRAP的免疫组化和降钙素受体的原位杂交明确RANKL阳性细胞的性质。结果:所有标本均显示RANKL阳性,阳性细胞位于牙源性角化囊肿的上皮层;均显示TRAP阳性,阳性细胞位于牙源性角化囊肿的上皮层,两种指标的阳性细胞定位类似;均显示CTR阳性,阳性细胞位于囊肿的上皮层,与RANKL和TRAP的阳性细胞定位类似。结论:RANKL在牙源性角化囊肿引起的颌骨破坏中起作用。Objectives: To detct the expression and distribution of RANKL in odontogenic keratocyst,and to explore the osteolytic mechanism of odontogenic keratocyst.Methods: RANKL and TRAP were detected by immunohistochemistry in 26 paraffin-embedded specimens of odontogenic keratocyst,and the CTR was detected by hybridization in situ.Results: All specimens showed positive immunoreactivity to RANKL and TRAP.CTR mRNA was detected in all specimens.These stained cells were located within the epithelial layer.The immunolocalization of RANKL was in concordance with the appearance of TRAP-positive cells and CTR-positive cells.Conclusion: RANKL plays a role in the bone resorption induced by odontogenic keratocyst.
关 键 词:核因子kB受体活化剂配体 牙源性角化囊肿 骨破坏
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