牙龈卟啉菌内毒素诱导人牙周纤维细胞释放细胞因子的实验研究  

Cytokine production of human periodontal ligament cells stimulated by porphyromonas gingivalis lipopolysaccharide

作　　者：李颖超[1,2] 马良[1,2] 谢玮 布静秋[1,2] 郝秀华[1,2] 颜光涛[1,2] 

机构地区：[1]解放军总医院口腔科 [2]解放军总医院生物化学研究室

出　　处：《军医进修学院学报》1999年第1期48-49,共2页Academic Journal of Pla Postgraduate Medical School

基　　金："九五"军队医药卫生科研基金

摘　　要：目的：研究牙龈卟啉菌内毒素诱导人牙周纤维细胞释放白细胞介素６（ＩＬ－６）和肿瘤坏死因子（ＴＮＦ）的影响。方法：放射免疫检测法。结果：表明人牙周纤维细胞在牙龈卟啉菌内毒素作用下释放ＩＬ－６，而不能释放ＴＮＦ。Objective: To reseach the function of human preiodontal ligament cell productions interleukin 6 (IL 6) and tumor necrosis factor (TNF) in response to porphyromonas gingivalis lipopolysaccharide (P.G LPS). Methods: IL 6 and TNF was measured by radioimmunoassay. Results:IL 6 was released from human preiodontal ligament cells stimulated by P. g LPS, but TNF was not produced. Conclusion:The amount of IL 6 is related with the concentration of P.g LPS in cell culture medium and the time of action.

关 键 词：细胞因子 牙周纤维细胞 卟啉菌 内毒素 

分 类 号：R781.402[医药卫生—口腔医学]