DS-1226对环磷酰胺所致小鼠骨髓抑制的保护作用  

Effeet of DS-1226 on Myelosuppression of Mice Caused by Cyclophosphamide

作　　者：许秋霞[1] 杨艳艳[1] 徐淑萍[1] 孙丽华[1] 马丽焱[1] 王立为[1] 刘新民[1] 王天山 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,北京100193 [2]加拿大天马药业集团公司 [3]大连泓亿北美人参制品有限公司,大连116600

出　　处：《世界科学技术-中医药现代化》2010年第2期245-249,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科技部国家"863"课题(2006AA02Z4Z2):儿童急性淋巴细胞白血病个性化治疗关键技术研究;负责人:刘新民

摘　　要：目的:探讨DS-1226胶囊对环磷酰胺所致小鼠骨髓抑制的影响。方法:将小鼠随机分为5组,正常对照组、模型组、DS-12263个剂量组(37.5、75、150mg·kg-1·d-1)。模型组、DS-1226组腹腔注射环磷酰胺(200mg·kg-1)造模,同时DS-1226组给予不同剂量的DS-1226灌胃,对照组、模型组给予蒸馏水灌胃,共8d。检测小鼠的一般状况、外周血象、骨髓有核细胞、骨髓结构、胸腺指数及淋巴细胞转化率。结果:DS-1226能改善骨髓抑制小鼠的一般状况,升高外周血象和骨髓有核细胞数量,促进骨髓腔内造血组织的增生,提高胸腺指数及淋巴细胞转化率。结论:DS-1226具有改善环磷酰胺所致小鼠骨髓抑制的作用,其机制可能与增强免疫功能,促进造血功能恢复有关。This study aimed to investigate the effect of capsule formulation of DS-1226 on cyclophosphamide-induced myelosuppression in mice. Mice were randomized into five groups： the control group, the CTX group and three treatment groups respectively at the dose of 37.5, 75, and 150 mg·kg^-1·d-1 DS-1226 capsule content. After one bolus intraperitoneal injection of 200 mg·kg-1 cyclophosphamide, the treatment groups were orally administrated with DS-1226 capsule decoction at different dosages for 8 days, while the control group and the CTX group were given distilled water. The general condition, peripheral blood cell counts, bone marrow nucleated cells, bone marrow structure, the thymus index and the lymphocyte transformation rate were examined. The results showed that DS- 1226 could improve the general condition, increase peripheral blood counts of leucocytes, lymphocytes, erythroeytes and bone marrow nucleated cells, promote hematopoiesis in bone marrow cavities, and stimulate the thymus index and the lymphocyte transformation rate. The hematopoietic effect of DS-1226 may help mitigate cyclophosphamideinduced myelosuppression and promote immunity in mice.

关 键 词：DS-1226 环磷酰胺 骨髓抑制 免疫功能 

分 类 号：R730.53[医药卫生—肿瘤]