乳腺良恶性病变组织c-met蛋白和转化生长因子α的表达及意义  

THE EXPRESSIONS AND SIGNIFICANCE OF C MET ONCOPROTEIN, TRANSFORMING GROWTH FACTOR α IN BENIGN AND MALIGNANT LESIONS OF BREAST

作　　者：陈显玉[1,2] 喻梅英[1,2] 杨竹林[1,2] 文继舫[1,2] 颜亚晖[1,2] 

机构地区：[1]湖南医科大学第二附属医院普外科 [2]湖南医科大学病理学教研室

出　　处：《中国普外基础与临床杂志》1999年第2期81-82,共2页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：应用免疫组化法测定５０例乳腺癌和１２例乳腺良性病变组织中ｃｍｅｔ蛋白及转化生长因子α（ＴＧＦα）的表达。结果：乳腺癌组织中ｃｍｅｔ蛋白及ＴＧＦα表达阳性率分别为２６．０％和４２．０％，乳腺良性病变组织中两者表达阳性率分别为８．３％和２５．０％；组织学分级为Ⅰ级，雌激素受体（ＥＲ）、孕激素受体（ＰＲ）及癌胚抗原（ＣＥＡ）为阴性的病例中，ｃｍｅｔ蛋白及ＴＧＦα表达阳性率明显低于组织学分级Ⅲ级，ＥＲ、ＰＲ及ＣＥＡ为阳性者（ｃｍｅｔ及ＰＲＰ＜０．０１；ＴＧＦα、ＰＲ和ＣＥＡＰ＜０．０５；余Ｐ＞０．０５）。The expressions and significance of c met oncoprotein and transforming growth factor α (TGF α) were studied by immunohistochemical method in 50 cases of breast cancer (BC) and 12 cases of benign lesions of breast (BL). The positive rate of c met, TGF α in BC was 26.0% and 25.0% respectively, in BL was 8.3% and 25.0% respectively. The positive rate of c met oncoprotein was lower in the cases of histologic Grade Ⅰ, positive of ER and PR or CEA than that of histologic Grade Ⅲ, negative of ER and PR or CEA. The positive rate of TGF α was lower in the cases of histologic Grade Ⅰ, negative of ER and PR or CEA than that of histologic Grade Ⅲ, positive of ER and PR or CEA. These results suggest the expression of c met and TGF α might be related to the carcinogenesis and development or endocrine state of BC.

关 键 词：乳腺肿瘤 原癌基因蛋白 转化生长因子 免疫组化 

分 类 号：R737.902[医药卫生—肿瘤]