963例成熟T和自然杀伤细胞／T细胞淋巴瘤的临床病理特征分析  

Clinicopathologic study of 963 cases of mature T-cell and natural killer/T-cell lymphoma with respect to 2008 WHO classification of lymphoid neoplasms

作　　者：梁琼[1] 叶子茵[2] 苏祖兰[1] 林汉良[2] 邵春奎[1] 林素暇[3] 饶慧兰[3] 梅开勇[1] 赵彤[4] 刘艳辉[5] 罗东兰[5] 朱梅刚 陈少红 林桐榆[3] 

机构地区：[1]中山大学附属第三医院病理科,广州510630 [2]中山大学附属第一医院病理科 [3]中山大学附属肿瘤医院病理科 [4]南方医科大学南方医院病理科 [5]广东省人民医院病理科 [6]广州金域检验中心

出　　处：《中华病理学杂志》2010年第5期291-295,共5页Chinese Journal of Pathology

摘　　要：目的观察广东地区不同类型成熟T和自然杀伤（NK）细胞／T细胞淋巴瘤及其亚型的临床病理特点。方法按WHO（2008版）标准重新评估广东地区2002—2006年1137例成熟T和NK／T细胞淋巴瘤患者。由多名血液病理医师复查，补做必要的免疫组织化学染色及原位杂交。结果963例确诊为成熟T和NK／T细胞淋巴瘤，占同期所有淋巴瘤20．1％（963／4801），发生于结内319例（33．1％），结外644例（66．9％）；非特殊型外周T细胞淋巴瘤293例（30．4％）；结外鼻型NK／T细胞淋巴瘤281例（29．2％）；间变性大细胞淋巴瘤（ALCL）198例（20．6％）；血管免疫母细胞性T细胞淋巴瘤（AILT）46例（4．8％）。男女比为1．99：1，发病中位年龄为44岁。非特殊型外周T细胞淋巴瘤好发于55～64岁；结外鼻型NK／T细胞淋巴瘤好发于25～54岁；间变性淋巴瘤激酶（ALK）阳性ALCL多见于年轻人而阴性多见于中老年人；AILT好发于65～74岁。结论广东地区成熟T和NK／T细胞淋巴瘤多见于结外，好发于男性，总体发病与年龄增长无明显关系，但具体类型有不同的年龄侧重群；常见的类型依次为非特殊型外周T细胞淋巴瘤、结外鼻型NK／T细胞淋巴瘤及ALCL；EB病毒感染与NK／T细胞淋巴瘤关系密切。Objective To study the clinicopathologie features of various types of mature T-cell and natural killer （NK）/T-eell lymphoma in Guangdong, China, with respect to the 2008 WHO classification of lymphoid neoplasms. Methods Eleven hundred and thirty-seven （1137 ） cases of mature T-cell or NK/T-cell lymphoma diagnosed during the period from 2002 to 2006 in Guangzhou area were retrieved. The clinical data, histologie features and immunohistoehemical findings were reviewed by a panel of experienced hematopathologists. Additional immunostaining was performed if indicated. The cases were re-classified according to the 2008 WHO classification of lymphoid neoplasms. Results Nine hundred and sixty-three （963） cases fulfilled the diagnostic criteria of mature T-cell or NK/T-cell lymphoma and accounted for 20. 1% of all cases of lymphoma encountered during the same period （963/4801）. A predominance of extranodal involvement was noted in 644 cases （66. 9% ） , while 319 cases （33.1%） showed mainly nodal disease. The prevalence of various lymphoma subtypes was as follows： peripheral T-cell lymphoma, unspecified （PTCL, NOS） 293 cases （30.4%）, extranodal NIL/T-cell lymphoma, nasal type 281 cases （29. 2% ） , anaplastic large cell lymphoma （ALCL） 198 cases （20. 6% ） , and angioimmunoblastic T-cell lymphoma （AILT） 46 cases （4. 8% ）. The male-to-female ratio was 1.99. The median age of the patients was 44 years, with the peak age of PTCL, NOS, extranodal NK/T-cell lymphoma, nasal type and AILT being 55 to 64 years, 25 to 54 years and 65 to 74 years, respectively. ALK-positive ALCL occurred more frequently in young age, while the ALK-negative ALCL cases occurred mainly in the elderly. Conclusions Extranodal lesions predominate in mature T-cell and NIL/T-cell lymphomas occurring in Guangzhou area. There is a male predominance and the overall incidence shows no increasing trend with age of the patient. The peak age of various subtypes however varies. The most common subtype was PTCL, N

关 键 词：淋巴瘤 T细胞 杀伤细胞 天然 病理学 临床 

分 类 号：R733.1[医药卫生—肿瘤]